CAJ | 학술논문

目的：探讨了以P53蛋白为代表的分子切缘与常规细胞病理切缘的关系以及切除肿瘤各边缘5．0 cm的组织是否安全可靠．方法：对49例胃肠道恶性肿瘤的瘤中心组织及肿瘤边缘每隔0．5 cm取材至上、下切缘5．0 cm处，采用免疫组化S-P法检测P53蛋白，并与对应位点的病理切片相比较．结果：距肿瘤切缘愈远，P53蛋白表达率愈低．P53蛋白阳性表达与细胞病理切缘阳性在各位点上相一致．在胃癌中，上切缘阳性范围不超过2．5 cm，下切缘不超过3．0 cm；在大肠癌中，上切缘阳性不超过1．0 cm，下切缘阳性不超过1．5 cm．结论：以P53为代表的分子切缘的概念可补充细胞切缘的概念，两者结合有助于提高病理诊断的准确性和可信度．距胃肠道恶性肿瘤各边缘5．0 cm的切缘范围是安全可靠的．
목적：탐토료이P53단백위대표적분자절연여상규세포병리절연적관계이급절제종류각변연5．0 cm적조직시부안전가고．방법：대49례위장도악성종류적류중심조직급종류변연매격0．5 cm취재지상、하절연5．0 cm처，채용면역조화S-P법검측P53단백，병여대응위점적병리절편상비교．결과：거종류절연유원，P53단백표체솔유저．P53단백양성표체여세포병리절연양성재각위점상상일치．재위암중，상절연양성범위불초과2．5 cm，하절연불초과3．0 cm；재대장암중，상절연양성불초과1．0 cm，하절연양성불초과1．5 cm．결론：이P53위대표적분자절연적개념가보충세포절연적개념，량자결합유조우제고병리진단적준학성화가신도．거위장도악성종류각변연5．0 cm적절연범위시안전가고적．
Objective:The relationship between molecular margin represented by P53 protein andtraditional cell pathological margin, the security and reliability to section 5.0 cm tissue fromgastrointestinal tumor margin is discussed. Methods:In 49 cases of gastrointestinal carcinoma,specimens were get from tumors′ central tissue and every 0.5 em from proximal tumor marginto distal. Immunohistochemistry was used to find P53 expression, then compared with cellpathological margin correspondly. Result: The farther distance of tumor margin, the lowerexpression of P53 protein. In gastric cancer, the distance of proximal margin of P53 positive isless than 2.5 em, while distal margin of P53 positive is less than 3cma; in colorectal cancer, thedistance of P53 positive is less than lcm in proximal margin and less than 1.5 cm in distal one.Conclusion: The concept of molecular margin complements the concept of cell pathologicalmargin. It may be helpful to enhance the precise and reliability of pathological diagnosis.Dissection 5cm from tumor is secure and reliable.