西安交通大学学报(英文版)
西安交通大學學報(英文版)
서안교통대학학보(영문판)
JOURNAL OF XI'AN MEDICAL UNIVERSITY
2002年
1期
81-85
,共5页
李丽君%余卓文%耿淑仁%王志勇%李骞%段学蕴%乔义超
李麗君%餘卓文%耿淑仁%王誌勇%李鶱%段學蘊%喬義超
리려군%여탁문%경숙인%왕지용%리건%단학온%교의초
hypertension%endothelium%genetics%ultrasonography
Objective To investigate whether endothelial dysfunction occurred in genetically vulnerable normotensive patients. Methods Endothelial function was assessed by high-resolution vascular ultrasound. The diameter of brachial arter i es were measured at rest, during reactive hyperemia and after sublingual nitrogl ycerine (GTN) in 70 young subjects with a mean age of 44.7 ( 12.1 years. Among t hem, there were 30 patients with essential hypertension (group 1), 20 normotensi ve patients with a family history of hypertension (group 2) and 20 normotensive patients without a family history of cardiovascular diseases that served as cont rols (group 3). Results Flow-mediated dilatation of brachial arteries was sig nificantly reduced in-group 1 and 2 when compared to group 3 (Group 1: 6.8( 3.9 vs group 2:8.0 (3.6 vs group 3:13.2 (5.9%, P<0.01). Conclusion Endothelium-dependent vasodilatation was impaired in the young normotensive patients with a family history of hypertension.
