现代康复
現代康複
현대강복
MODERN REHABILITATION
2001年
8期
156-157
,共2页
陈礼刚%高立达%曾凡俊%顾明%李讯%黄茂清%毛伯镛
陳禮剛%高立達%曾凡俊%顧明%李訊%黃茂清%毛伯鏞
진례강%고립체%증범준%고명%리신%황무청%모백용
Objective To approach the effect of microgene pSVPoMcat modified Schwann cell (SC) on the regeneration and repair of injured spinal cord.Method Spinal cord hemi－ transection models were made with the cutting method in healthy SD rats. Microgene pSVPoMcat modified SC(group A),highly purified SC(group B),and glutin sponge (control group C)were randomly implanted into the cut. After 3 month living ,the host rats were scanned by MRI, and observed under EM. Result Spinal signals at the injury region nearly recovered to normal in group A.No recovery was found in group B.Malacosis was found in group C.TEM findings: regeneration of large number of myelinated and nonmyelinated axons and SC proliferation in group A, myelinated axon regeneration and SC necrosis in group B, non myelinated and nonmyelinated axon in group C.Conclusion Implantation of microgene pSVPoMcat modified SC could promote the repair of injured spinal cord.
