CAJ | 학술논문

目的对国产硫酸特布他林注射液治疗支气管哮喘和慢性喘息型支气管炎的有效性与安全性进行评价。方法分别采用国产硫酸特布他林注射液(试验组)和进口博利康尼注射液(对照组)治疗支气管哮喘和慢性喘息型支气管炎患者各60例。试验药与对照药均为0.25mg/次，每日3次，静脉滴注给药，疗程3～5天。结果试验组和对照组的临床显效率分别为66.7%和73.3%(P>0.05);总有效率分别为98.3%和100.0%(P>0.05)。肺功能改善显效率分别为78.4%和76.6%;总有效率分别为88.3%和90.0%(P>0.05)。临床综合疗效分析显示，试验组与对照组的显效率均为61.6%,(P>0.05);总有效率分别为88.3%和90.0%(P>0.05)。两组的不良反应发生率分别为13.3%和15.0%，多为轻度，勿需处理及中断治疗。结论国产硫酸特布他林注射液是一安全有效的平喘药。
목적 대국산류산특포타림주사액치료지기관효천화만성천식형지기관염적유효성여안전성진행평개。방법 분별채용국산류산특포타림주사액(시험조)화진구박리강니주사액(대조조)치료지기관효천화만성천식형지기관염환자각60례。시험약여대조약균위0.25mg/차，매일3차，정맥적주급약，료정3～5천。결과 시험조화대조조적림상현효솔분별위66.7%화73.3%(P>0.05);총유효솔분별위98.3%화100.0%(P>0.05)。폐공능개선현효솔분별위78.4%화76.6%;총유효솔분별위88.3%화90.0%(P>0.05)。림상종합료효분석현시，시험조여대조조적현효솔균위61.6%,(P>0.05);총유효솔분별위88.3%화90.0%(P>0.05)。량조적불량반응발생솔분별위13.3%화15.0%，다위경도，물수처리급중단치료。결론 국산류산특포타림주사액시일안전유효적평천약。
Objective This multi-centered clinical trial was designed toassess the effica cy and safety of domestic intravenous Turbutalin Sulfate in the treatment of ast hma and chronic asthmatic bronchitis. Methods Bricanyl was used as control. A total of 120 patients were included in this randomized controlled study. The two medicati ons, both at a dose of 0.25 mg intravenous drip, were given three times a day fo r 3-5 days.Results The two drugs' clinical excellent rates wer e 6 6.7% and 73.3%; overall efficacy rates were 98.3% and 100.0%, respectively. Thei r pulmonary functional excellent rates were 78.4% and 76.6%; overall effect rate s were 88.3% and 90.0%, respectively. Composite curative evaluation showed that t he two drug's composite excellent rates were 61.6% both; their overall efficacy rates were 88.3% and 90.0%, respectively. All of these showed no significant dif ference (P>0.05). The incidence rates of adverse side effects of the two gro ups were 13.5% and 15.0%, respectively; most of them were mild and tolerable. [ WTHZ Conclusion Domestic intravenous Terbutalin Sulfate is effective and safe in treating asthma and chronic asthmatic bronchitis.