CAJ | 학술논문

DKK-1（Dickkopf-1）蛋白作为Wnt信号通路的抑制因子之一，可通过竞争性结合脂蛋白受体相关蛋白5/6（LRP 5/6），也可通过与跨膜蛋白kremen、LRP 5/6形成三元复合物而导致快速内吞，减少质膜LRP 5/6而抑制Wnt信号通路。近期研究发现DKK-1在抗肿瘤、抗组织器官纤维化、调节骨代谢、预测心脑血管事件发生等方面发挥重要作用，从而为临床诊断治疗提供了新的思路。本文旨对DKK-1的实验研究进展进行综述。
DKK-1（Dickkopf-1）단백작위Wnt신호통로적억제인자지일，가통과경쟁성결합지단백수체상관단백5/6（LRP 5/6），야가통과여과막단백kremen、LRP 5/6형성삼원복합물이도치쾌속내탄，감소질막LRP 5/6이억제Wnt신호통로。근기연구발현DKK-1재항종류、항조직기관섬유화、조절골대사、예측심뇌혈관사건발생등방면발휘중요작용，종이위림상진단치료제공료신적사로。본문지대DKK-1적실험연구진전진행종술。
DKK-1 (Dickkopf-1),as one of the inhibitors of Wnt signaling pathway,block Wnt signaling pathway by competitive binding lipoprotein-receptor-related proteins 5 and 6 (LRP 5/6) or forming a ternary complex with kremen and LRP 5/6, which induces rapid endocytosis and removal of the Wnt receptor LRP 5/6 from the plasma membrane. Recently, research shows that DKK-1 play an important role in anti-tumor therapy, anti fibrosis of tissue and organ therapy, regulating bone metabolism and predicting the risk of cardiovascular events etc, which provide a new idea for clinical diagnosis and treatment. The paper will review advances in the experimental research of DKK-1.