CAJ | 학술논문

目的探讨搏动性导管(pulsatile catheter, PUCA)泵在心脏复苏中的应用,为临床抢救心跳骤停的患者提供一种新的思路.方法健康绵羊11只,致室颤心脏停跳行心脏复苏,根据有无PUCA泵辅助及辅助是否及时分三组:无辅助(n=3)、延迟辅助(n=2)和即时辅助(n=6),记录并比较3组复苏所持续时间和成败率.分别于复苏后5 min、60 min和180 min监测并记录血流动力学参数.结果无辅助、延迟辅助和即时辅助复苏持续时间分别为(38.3±5.8) min、(43.5±9.2) min和(48.7±23.8) min,3组比较差异无显著性(P＞0.05);3组成败比分别为0/3、0/2和5/1,差异有显著性(P＜0.05).复苏成功的5只绵羊在支持期间血流动力学逐步恢复并趋向稳定,血压在辅助180 min与5 min相比有明显的统计学意义(P＜0.05).结论心跳骤停中,在PUCA泵即时辅助下行心脏复苏明显提高复苏成功率,并能恢复和稳定复苏动物的血流动力学;该结果可望拓展PUCA泵在临床上新的应用.
목적탐토박동성도관(pulsatile catheter, PUCA)빙재심장복소중적응용,위림상창구심도취정적환자제공일충신적사로.방법건강면양11지,치실전심장정도행심장복소,근거유무PUCA빙보조급보조시부급시분삼조:무보조(n=3)、연지보조(n=2)화즉시보조(n=6),기록병비교3조복소소지속시간화성패솔.분별우복소후5 min、60 min화180 min감측병기록혈류동역학삼수.결과무보조、연지보조화즉시보조복소지속시간분별위(38.3±5.8) min、(43.5±9.2) min화(48.7±23.8) min,3조비교차이무현저성(P＞0.05);3조성패비분별위0/3、0/2화5/1,차이유현저성(P＜0.05).복소성공적5지면양재지지기간혈류동역학축보회복병추향은정,혈압재보조180 min여5 min상비유명현적통계학의의(P＜0.05).결론심도취정중,재PUCA빙즉시보조하행심장복소명현제고복소성공솔,병능회복화은정복소동물적혈류동역학;해결과가망탁전PUCA빙재림상상신적응용.
Objective To assess the effect of the pulsatile catheter (PUCA) pump support on cardiac resuscitation in sheep,and to provide a new approach for saving cardiac arrest patients. Methods Cardiac arrest was induced by ventricular fibrillation in 11 sheep. These sheep were divided into three groups including no support (n=3), delayed support (n=2) and immediate support (n=6). Time for cardiac resuscitation and the ratio of success to failure in each group were recorded. Hemodynamic parameters including heart rate (HR), cardiac output (CO), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), central venous pressure(CVP),right ventricular end-diastolic pressure (RVEDP),left atrial pressure (LAP), and left ventricular end-diastolic pressure (LVEDP) were monitored and recorded at 5, 60 and 180 min after cardiac resuscitation with PUCA pump. Results Time for cardiac resuscitation in no support group, delayed support group and immediate support group was (38.3±5.8),(43.5±9.2) and (48.7±23.8)minutes, respectively(P＞0.05),and the ratio of success to failure was 0/3,0/2 and 5/1, respectively ( P＜0.05). After cardiac resuscitation with the PUCA pump support, MAP, SBP and DBP increased gradually(P＜0.05).Conclusions PUCA pump can maintain the hemodynamic stability in a sheep model of cardiac arrest,and can thus increase the success rate of cardiac resuscitation. It may be suitable for resuscitating cardiac arrest patients.