CAJ | 학술논문

目的探讨血浆氨基末端B型钠尿肽前体(NT-proBNP)及组织多普勒成像评价左室舒张功能不全的价值.方法选择舒张性心力衰竭患者43例,根据舒张早期二尖瓣口血流速度(E)与舒张早期二尖瓣环运动速度(Em)的比值将患者分为三组:E/Em＜8为Ⅰ组,E/Em 8～15为Ⅱ组,E/Em＞15为Ⅲ组.测定三组患者血浆NT-proBNP水平,并进行比较.结果 Ⅲ组NT-proBNP水平[(1119±3123)ng/L]显著高于Ⅱ组[(684±1742)ng/L]和Ⅰ组[(276±438)ng/L](P＜0.01),Ⅱ组NT-proBNP水平显著高于Ⅰ组(P＜0.01).相关性分析表明E/Em与NT-proBNP具有相关性(r=0.438,P＜0.01).结论血浆NT-proBNP水平及组织多普勒成像可用于评价左室舒张功能不全.
목적 탐토혈장안기말단B형납뇨태전체(NT-proBNP)급조직다보륵성상평개좌실서장공능불전적개치.방법 선택서장성심력쇠갈환자43례,근거서장조기이첨판구혈류속도(E)여서장조기이첨판배운동속도(Em)적비치장환자분위삼조:E/Em＜8위Ⅰ조,E/Em 8～15위Ⅱ조,E/Em＞15위Ⅲ조.측정삼조환자혈장NT-proBNP수평,병진행비교.결과 Ⅲ조NT-proBNP수평[(1119±3123)ng/L]현저고우Ⅱ조[(684±1742)ng/L]화Ⅰ조[(276±438)ng/L](P＜0.01),Ⅱ조NT-proBNP수평현저고우Ⅰ조(P＜0.01).상관성분석표명E/Em여NT-proBNP구유상관성(r=0.438,P＜0.01).결론 혈장NT-proBNP수평급조직다보륵성상가용우평개좌실서장공능불전.
Objective To evaluate the value of N-terminal prohormone brain natriuretic peptide (NT-proBNP) and tissue Doppler imaging (TDI) in patients with left ventricular diastolic dysfunction.Methods Forty-three patients with diastolic heart failure were enrolled. Pulsed wave (PW) Doppler technology was used to detect early diastolic mitral velocity (E) and TDI was performed to determine the mitral annulus velocity of early diastolic phase (Em). According to the E/Em, patients were divided into three groups: group Ⅰ (E/Em ＜8),group Ⅱ (E/Em 8-15) and group Ⅲ (E/Em ＞ 15). The plasma NT-proBNP was measured. Results The plasma NT-proBNP in group Ⅲ [( 1119 ± 3123) ng/L] was higher than that in group Ⅱ [(684± 1742) ng/L] and group Ⅰ [(276±438) ng/L] (P＜0.01),and the plasma NT-proBNP in group Ⅱ was higher than that in group Ⅰ (P ＜ 0.01 ). The plasma NT-proBNP had positive correlation with E/Em (r = 0.438,P ＜ 0.01 ). Conclusion The plasma NT-proBNP and TDI are useful to evaluate the left ventricular diastolic dysfunction.