中华急诊医学杂志
中華急診醫學雜誌
중화급진의학잡지
CHINESE JOURNAL OF EMERGENCY MEDICINE
2011年
3期
273-276
,共4页
急性有机磷中毒%敌敌畏%中毒%大鼠%血流动力学%肌钙蛋白T%心房利钠肽%心肌损伤
急性有機燐中毒%敵敵畏%中毒%大鼠%血流動力學%肌鈣蛋白T%心房利鈉肽%心肌損傷
급성유궤린중독%활활외%중독%대서%혈류동역학%기개단백T%심방리납태%심기손상
Dichlorvos%Rat%Hemodynamic%CTnT%Myocardial injury
目的 研究急性敌敌畏(dichlorvos,DDVP)中毒导致的早期心肌损伤表现.方法 Sprague Dawley(SD)大鼠24只,随机(随机数字法)分成对照组和中毒组两组,每组12只.采用右侧颈动脉置管术动态监测有创血流动力学指标;测定血清肌钙蛋白T(cardiac troponin T,CTnT)和心房利钠肽(brain natriuretic peptide,BNP)水平;观察心肌组织病理学改变.结果 ①中毒组自身前后对照:中毒1 h内,心率(heart rate,HR)和室内压上升段最大变化率(maximum ascending rates of left ventricular pressure,+dp/dtmax)均有显著下降;室内压下降段最大变化率(maximum descending rates of left ventricular pressure,-dp/dtmax),左室舒张末压(1eft ventricular end diastolic pressure,LVEDP)有显著升高(P＜0.01).其中均以7 min时改变最显著.②中毒组与对照组比,血清CTnT值显著升高(P＜0.01),血清BNP值差异无统计学意义(P＞0.05).③中毒组心肌HE染色存在病理学损害.结论 急性有机磷中毒(acute organophosphorus pesticides poisoning,AOPP)其早期可导致大鼠心肌损伤,血流动力学紊乱,心功能受抑.CTnT可作为早期评价AOPP心肌损伤的指标,而BNP在AOPP诊治中的意义不大.
目的 研究急性敵敵畏(dichlorvos,DDVP)中毒導緻的早期心肌損傷錶現.方法 Sprague Dawley(SD)大鼠24隻,隨機(隨機數字法)分成對照組和中毒組兩組,每組12隻.採用右側頸動脈置管術動態鑑測有創血流動力學指標;測定血清肌鈣蛋白T(cardiac troponin T,CTnT)和心房利鈉肽(brain natriuretic peptide,BNP)水平;觀察心肌組織病理學改變.結果 ①中毒組自身前後對照:中毒1 h內,心率(heart rate,HR)和室內壓上升段最大變化率(maximum ascending rates of left ventricular pressure,+dp/dtmax)均有顯著下降;室內壓下降段最大變化率(maximum descending rates of left ventricular pressure,-dp/dtmax),左室舒張末壓(1eft ventricular end diastolic pressure,LVEDP)有顯著升高(P＜0.01).其中均以7 min時改變最顯著.②中毒組與對照組比,血清CTnT值顯著升高(P＜0.01),血清BNP值差異無統計學意義(P＞0.05).③中毒組心肌HE染色存在病理學損害.結論 急性有機燐中毒(acute organophosphorus pesticides poisoning,AOPP)其早期可導緻大鼠心肌損傷,血流動力學紊亂,心功能受抑.CTnT可作為早期評價AOPP心肌損傷的指標,而BNP在AOPP診治中的意義不大.
목적 연구급성활활외(dichlorvos,DDVP)중독도치적조기심기손상표현.방법 Sprague Dawley(SD)대서24지,수궤(수궤수자법)분성대조조화중독조량조,매조12지.채용우측경동맥치관술동태감측유창혈류동역학지표;측정혈청기개단백T(cardiac troponin T,CTnT)화심방리납태(brain natriuretic peptide,BNP)수평;관찰심기조직병이학개변.결과 ①중독조자신전후대조:중독1 h내,심솔(heart rate,HR)화실내압상승단최대변화솔(maximum ascending rates of left ventricular pressure,+dp/dtmax)균유현저하강;실내압하강단최대변화솔(maximum descending rates of left ventricular pressure,-dp/dtmax),좌실서장말압(1eft ventricular end diastolic pressure,LVEDP)유현저승고(P＜0.01).기중균이7 min시개변최현저.②중독조여대조조비,혈청CTnT치현저승고(P＜0.01),혈청BNP치차이무통계학의의(P＞0.05).③중독조심기HE염색존재병이학손해.결론 급성유궤린중독(acute organophosphorus pesticides poisoning,AOPP)기조기가도치대서심기손상,혈류동역학문란,심공능수억.CTnT가작위조기평개AOPP심기손상적지표,이BNP재AOPP진치중적의의불대.
Objective To investigate the myocardial injury in the early stage of acute dichlorvos poisoning in rats. Method A total of 24 Sprague Dawley rats were randomly (random number) divided into control group(n = 12) and poisoning group(n = 12). Hemodynamic variables were monitored by using an arterial cannula inserted into right arteria carotis communis. Serum levels of cardiac troponin T(CTnT) and brain natriuretic peptide (BNP) were measured. Myocardial tissue was observed with HE stain under microscope. Results The rats of poisoning group showed that the heart rate (HR) and maximum ascending rates of left ventricular pressure(+ dp/dtmax)were significant decreased in an hour after poisoning (P ＜0.01). The maximum descending rates of left ventricular pressure(-dp/dtmax)and left ventricular end diastolic pressure (LVEDP)were markedly increased (P＜0. 01) and reached peak in 7 minutes in the poisoning group. Compared with the control group, cardiac troponin T obviously changed in rats poisoned with dichlorvos in the first hour. BNP was not affected after poisoning(P ＞ 0. 05). Myocardial damage was found in the poisoning rats.Conclusions Myocardial injury and heart failure occurred in the early stage of acute organophosphorus pesticides poisoning(AOPP) in rats. CTnT could play a major role in AOPP while BNP might not be involved in.
