中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
6期
519-521
,共3页
刘同赏%郭彩宏%罗向军%李芳芳%丁灵芝
劉同賞%郭綵宏%囉嚮軍%李芳芳%丁靈芝
류동상%곽채굉%라향군%리방방%정령지
肺疾病,阻塞性%C反应蛋白%纤维蛋白原%前白蛋白
肺疾病,阻塞性%C反應蛋白%纖維蛋白原%前白蛋白
폐질병,조새성%C반응단백%섬유단백원%전백단백
Lung disease%Obstructive%C-reactive protein%Fibrinogen%Prealbumin
目的 探讨慢性阻塞性肺疾病急性加重期患者血清C反应蛋白、纤维蛋白原及前白蛋白的含量变化及临床意义.方法 采用速率散射比浊法分别检测30例慢性阻塞性肺疾病患者急性加重期、缓解期及30例体检者血清C反应蛋白、纤维蛋白原及前白蛋白的含量,同时测定其第1秒用力呼气容积占预计值百分比(FEV1%)及动脉血氧分压(PaO2).结果 ①慢性阻塞性肺疾病急性加重期及缓解期血清C反应蛋白及纤维蛋白原较对照组均明显升高,差异有统计学意义(F值分别为151.61和70.45,均P＜0.05,q值分别为22.40,8.30;16.72,7.12;均P＜0.05);而慢性阻塞性肺疾病急性加重期及缓解期血清前自蛋白较对照组均明显降低,差异有统计学意义(F=33.83,P＜0.05,q值分别为15.26,6.31,P均＜0.05).②急性加重期患者治疗后处于缓解期时C反应蛋白及纤维蛋白原均明显降低,差异有统计学意义(q值分别等于20.06及9.61,均P＜0.05);而急性加重期患者治疗后处于缓解期时前白蛋白值明显升高(g=10.35,P＜0.05).③血清C反应蛋白及纤维蛋白原水平与FEV1%均呈负相关(r分别等于-0.73及-0.82,均P＜0.01);而血清前白蛋白水平与FEV1%均呈正相关(r=0.62,P＜0.05).④血清C反应蛋白及纤维蛋白原水平与PaO2亦均呈负相关(r=-0.81及-0.68,均P＜0.01);而血清前白蛋白水平与PaO2呈正相关(r=0.71,P＜0.05).结论 血清C反应蛋白、纤维蛋白原及前白蛋白的检测对于慢性阻塞性肺疾病急性加重临床和治疗效果判断具有一定意义.
目的 探討慢性阻塞性肺疾病急性加重期患者血清C反應蛋白、纖維蛋白原及前白蛋白的含量變化及臨床意義.方法 採用速率散射比濁法分彆檢測30例慢性阻塞性肺疾病患者急性加重期、緩解期及30例體檢者血清C反應蛋白、纖維蛋白原及前白蛋白的含量,同時測定其第1秒用力呼氣容積佔預計值百分比(FEV1%)及動脈血氧分壓(PaO2).結果 ①慢性阻塞性肺疾病急性加重期及緩解期血清C反應蛋白及纖維蛋白原較對照組均明顯升高,差異有統計學意義(F值分彆為151.61和70.45,均P＜0.05,q值分彆為22.40,8.30;16.72,7.12;均P＜0.05);而慢性阻塞性肺疾病急性加重期及緩解期血清前自蛋白較對照組均明顯降低,差異有統計學意義(F=33.83,P＜0.05,q值分彆為15.26,6.31,P均＜0.05).②急性加重期患者治療後處于緩解期時C反應蛋白及纖維蛋白原均明顯降低,差異有統計學意義(q值分彆等于20.06及9.61,均P＜0.05);而急性加重期患者治療後處于緩解期時前白蛋白值明顯升高(g=10.35,P＜0.05).③血清C反應蛋白及纖維蛋白原水平與FEV1%均呈負相關(r分彆等于-0.73及-0.82,均P＜0.01);而血清前白蛋白水平與FEV1%均呈正相關(r=0.62,P＜0.05).④血清C反應蛋白及纖維蛋白原水平與PaO2亦均呈負相關(r=-0.81及-0.68,均P＜0.01);而血清前白蛋白水平與PaO2呈正相關(r=0.71,P＜0.05).結論 血清C反應蛋白、纖維蛋白原及前白蛋白的檢測對于慢性阻塞性肺疾病急性加重臨床和治療效果判斷具有一定意義.
목적 탐토만성조새성폐질병급성가중기환자혈청C반응단백、섬유단백원급전백단백적함량변화급림상의의.방법 채용속솔산사비탁법분별검측30례만성조새성폐질병환자급성가중기、완해기급30례체검자혈청C반응단백、섬유단백원급전백단백적함량,동시측정기제1초용력호기용적점예계치백분비(FEV1%)급동맥혈양분압(PaO2).결과 ①만성조새성폐질병급성가중기급완해기혈청C반응단백급섬유단백원교대조조균명현승고,차이유통계학의의(F치분별위151.61화70.45,균P＜0.05,q치분별위22.40,8.30;16.72,7.12;균P＜0.05);이만성조새성폐질병급성가중기급완해기혈청전자단백교대조조균명현강저,차이유통계학의의(F=33.83,P＜0.05,q치분별위15.26,6.31,P균＜0.05).②급성가중기환자치료후처우완해기시C반응단백급섬유단백원균명현강저,차이유통계학의의(q치분별등우20.06급9.61,균P＜0.05);이급성가중기환자치료후처우완해기시전백단백치명현승고(g=10.35,P＜0.05).③혈청C반응단백급섬유단백원수평여FEV1%균정부상관(r분별등우-0.73급-0.82,균P＜0.01);이혈청전백단백수평여FEV1%균정정상관(r=0.62,P＜0.05).④혈청C반응단백급섬유단백원수평여PaO2역균정부상관(r=-0.81급-0.68,균P＜0.01);이혈청전백단백수평여PaO2정정상관(r=0.71,P＜0.05).결론 혈청C반응단백、섬유단백원급전백단백적검측대우만성조새성폐질병급성가중림상화치료효과판단구유일정의의.
Objective To investigate the changes of serum C-reactive protein (CRP), prealbumin(PA) and fibrinogen(Fbg) in patients of acute exacerbation of COPD(AECOPD).Methods The serum C-reactive protein,fibrinogen and prealbumin level were detected in 30 patients of AECOPD and COPD respectively and in 30 controls,meanwhile, their FEV1% and PaO2 also be measured.Results The serum CRP and Fbg level were apparently higher in the patients of both COPD and AECOPD than those in the controls (F=151.61 and 70.45 respectively,P＜0.05 ;q = 22.40, 8.30, 16.72 and 7.12 respectively, P ＜0.05) ;while the PA level was lower in the patients of both AECOPD and COPD than that in the controls(F = 33.83, P ＜ 0.05, q = 15.26 and 6.31, P ＜0.05).After treatment, the serum CRP and Fbg level in patients of AECOPD was significantly lower(q = 20.06 and 9.61 respectively, P ＜0.05) ; while the PA level was higher(q = 10.35, P ＜0.05).The serum CRP and Fbg level was negatively related with the FEV1% (r = - 0.73 and - 0.82 respectively, P ＜ 0.01).While the PA level was positively related with FEV1% (r = 0.62, P ＜ 0.05).The serum CRP and Fbg level was negatively related with PaO2 (r = -0.81 and -0.68 respectively, P＜ 0.01).While the PA level was positively related with PaO2 (r = 0.71, P＜0.05).Conclusions The detection of serum CRP, Fbg and PA level may be useful for the diagnosis and treatment of patients of AECOPD.
