CAJ | 학술논문

原发性肝癌的发生是一个多途径、多阶段、多基因的复杂过程,而HCC又是原发性肝癌中最重要的一种类型,等位基因的缺失及对应区域的抑癌基因失活在HCC发生、发展以及复发过程中起着十分重要的作用.人类多数常染色体以及Y染色体均发生与HCC有关的LOH,其中以1p,1q,4q,8p,10q,16q,17p上的等位基因缺失的报道最多.本文回顾了LOH在HCC临床诊治方面的研究,并对LOH在HCC早期诊断,治疗,预后以及易感性判断中的应用前景进行展望.
원발성간암적발생시일개다도경、다계단、다기인적복잡과정,이HCC우시원발성간암중최중요적일충류형,등위기인적결실급대응구역적억암기인실활재HCC발생、발전이급복발과정중기착십분중요적작용.인류다수상염색체이급Y염색체균발생여HCC유관적LOH,기중이1p,1q,4q,8p,10q,16q,17p상적등위기인결실적보도최다.본문회고료LOH재HCC림상진치방면적연구,병대LOH재HCC조기진단,치료,예후이급역감성판단중적응용전경진행전망.
The carcinogenesis of primary liver cancer is a complicated multi-factor, multi-step, multi-gene process.Hepatocellular carcinoma (HCC) is the most important type of primary liver cancer. Allele deletions and inactivation of tumor suppressor genes (TSGs) play critical roles during the carcinogenesis, progress and recurrence of HCC. Loss of heterozygosity (LOH) associated with HCC occurs at most autosomes and the Y chromosome. Losses at chromosomes 1p, 1q, 4q, 8p, 10q, 16q, and 17p have been documented frequently. In this article, we previewed the investigations of clinical significance of LOH, and looked forward to the application of LOH in early detection, therapy, and prediction of prognosis and susceptibility in HCC patients.