CAJ | 학술논문

由于甲型流感病毒基因高度变异的特点,导致其对不同种属宿主亲和力、毒力、免疫原性、抗药性不断发生变化,全球新型流感大流行的风险时刻存在.因此,应加强流感特别是重症流感发病机制和有效干预措施研究,从疫苗研制、开发新型抗病毒药、加强综合治疗,特别是调节宿主免疫反应等多个方面着手,为应对可能爆发的流感大流行提供对策.
유우갑형류감병독기인고도변이적특점,도치기대불동충속숙주친화력、독력、면역원성、항약성불단발생변화,전구신형류감대류행적풍험시각존재.인차,응가강류감특별시중증류감발병궤제화유효간예조시연구,종역묘연제、개발신형항병독약、가강종합치료,특별시조절숙주면역반응등다개방면착수,위응대가능폭발적류감대류행제공대책.
Due to the high frequencies of mutations, the tissue tropism, virulence,immunogenicity, and drug resistance of influenza A virus are changing, which shows that a future pandemic from a novel influenza virus is a real threat. The researches on pathogenesis and effective intervention strategies of influenza patients especially for severe cases should be strengthened from preparation of vaccine, development of new antiviral drugs, strengthening integrated treatment, and regulation of host immune response, which provide strategies for the possible outbreak of influenza pandemic.