CAJ | 학술논문

免疫作用在年龄相关性黄斑变性(AMD)的玻璃膜疣形成、视网膜色素上皮萎缩、脉络膜新生血管形成等病变形成过程中贯穿始终.视网膜为免疫赦免器官并维持自身免疫稳态,该稳态失衡时免疫反应过度则演变为慢性炎症,持久的炎症反应可导致眼内炎症细胞积累、补体分子积累、免疫复合物沉积,造成组织损伤.目前认为,免疫产物沉积于眼主要涉及慢性炎症、亚炎症、自我吞噬功能失代偿等机制.本文就近年来在视网膜老化、免疫异常、自我吞噬作用与AMD发生发展相关的研究进展做一综述.
면역작용재년령상관성황반변성(AMD)적파리막우형성、시망막색소상피위축、맥락막신생혈관형성등병변형성과정중관천시종.시망막위면역사면기관병유지자신면역은태,해은태실형시면역반응과도칙연변위만성염증,지구적염증반응가도치안내염증세포적루、보체분자적루、면역복합물침적,조성조직손상.목전인위,면역산물침적우안주요섭급만성염증、아염증、자아탄서공능실대상등궤제.본문취근년래재시망막노화、면역이상、자아탄서작용여AMD발생발전상관적연구진전주일종술.
Immune mechanism plays an important role in pathology of AMD,including formation of drusen,geographic atrophy and choroidal neovascularization (CNV). Retina is an " immune privileged" site,which could maintain immune homeostasis in one 's life. Disruption of this homeostatic mechanisms seems crucial in allowing excessive activation of immunologic response and the resultant chronic inflammation,which could lead to accumulation of resident immune cells,complement components and deposition of immune complex,all above may result in ocular tissue damage and degeneration.At present,deposition of immunoreactive products in ocular tissues is involved in chronic inflammation,para-inflammation,dysfunction of autophagy and so on.This article reviews recent studies on development of AMD relevant to retina aging,dysfunction of immunity and autophagy.