中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2009年
4期
453-455
,共3页
陈现亮%高善玲%郑庆芬%高俊霞%林静丽%赵磊
陳現亮%高善玲%鄭慶芬%高俊霞%林靜麗%趙磊
진현량%고선령%정경분%고준하%림정려%조뢰
Ki-67抗原%肿瘤抑制蛋白质类%胃肿瘤%息肉
Ki-67抗原%腫瘤抑製蛋白質類%胃腫瘤%息肉
Ki-67항원%종류억제단백질류%위종류%식육
Ki-67 antigen%Tumor suppressor proteins%Stomach neoplasms%Polyps
目的 研究p27kip1和ki67蛋白在不同类型胃息肉中的表达及其与胃息肉和胃癌的相互关系.方法 应用免疫组化法分别检测正常胃黏膜、增生性胃息肉、腺瘤性胃息肉及胃癌组织中p27kip1和ki67蛋白的表达.结果 p27kip1蛋白在正常胃黏膜组、增生性胃息肉组、腺瘤性胃息肉组和胃癌组中表达的阳性率分别为90.00%、70.00%、65.00%和30.43%,胃癌组明显低于其他三组.Ki67蛋白在正常胃黏膜组、增生性胃息肉组、腺瘤性胃息肉组和胃癌组中表达的阳性率分别为10.00%、15.00%、45.00%和73.33%,胃癌组明显高于其他三组,腺瘤性胃息肉组明显高于正常胃黏膜组和增生性胃息肉组,差异均有统计学意义(P<0.05).p27kip1和ki67蛋白在胃息肉中的表达无关(rs=-0.093,P>0.05).结论 检测胃息肉中p27kip1和ki67蛋白的表达,有助于早期诊断胃息肉癌变并判断其预后.
目的 研究p27kip1和ki67蛋白在不同類型胃息肉中的錶達及其與胃息肉和胃癌的相互關繫.方法 應用免疫組化法分彆檢測正常胃黏膜、增生性胃息肉、腺瘤性胃息肉及胃癌組織中p27kip1和ki67蛋白的錶達.結果 p27kip1蛋白在正常胃黏膜組、增生性胃息肉組、腺瘤性胃息肉組和胃癌組中錶達的暘性率分彆為90.00%、70.00%、65.00%和30.43%,胃癌組明顯低于其他三組.Ki67蛋白在正常胃黏膜組、增生性胃息肉組、腺瘤性胃息肉組和胃癌組中錶達的暘性率分彆為10.00%、15.00%、45.00%和73.33%,胃癌組明顯高于其他三組,腺瘤性胃息肉組明顯高于正常胃黏膜組和增生性胃息肉組,差異均有統計學意義(P<0.05).p27kip1和ki67蛋白在胃息肉中的錶達無關(rs=-0.093,P>0.05).結論 檢測胃息肉中p27kip1和ki67蛋白的錶達,有助于早期診斷胃息肉癌變併判斷其預後.
목적 연구p27kip1화ki67단백재불동류형위식육중적표체급기여위식육화위암적상호관계.방법 응용면역조화법분별검측정상위점막、증생성위식육、선류성위식육급위암조직중p27kip1화ki67단백적표체.결과 p27kip1단백재정상위점막조、증생성위식육조、선류성위식육조화위암조중표체적양성솔분별위90.00%、70.00%、65.00%화30.43%,위암조명현저우기타삼조.Ki67단백재정상위점막조、증생성위식육조、선류성위식육조화위암조중표체적양성솔분별위10.00%、15.00%、45.00%화73.33%,위암조명현고우기타삼조,선류성위식육조명현고우정상위점막조화증생성위식육조,차이균유통계학의의(P<0.05).p27kip1화ki67단백재위식육중적표체무관(rs=-0.093,P>0.05).결론 검측위식육중p27kip1화ki67단백적표체,유조우조기진단위식육암변병판단기예후.
Objective To study the expression of p27kip1 and Ki67 proteins in various types of gastric polyp and the relationship be-tween gastric polyp and gastric carcinoma (CA:). Methods The expression of p27kip1 and Ki67 proteins were detected in normal gastric mu-cosa, hyperplasie polyp, adenomatons polyp, and carcinoma by S-P immunohistochemical staining. Results In the normal gastric mucosa,hyperplasie polyp, adenomatous polyp and gastric carcinoma, the expression rate of the p27kip1 protein was 90. 00% ,70. 00% ,65.00% and 30. 43%, respectively. The positive rate of p27kip1 protein in gastric cancer was significantly lower than that in other tissues. The rate of Ki67 protein expression in those tissues was 10. 00%, 15.00%, 45.00%, and 73.33%, respectively. The positive rate of Ki67 protein in gastric cancer was significantly higher than that in other tissues. And the positive rate of Ki67 in adenomatous polyp was significantly higher than that in the normal gnstric mucosa and hyperplasic polyp. There were significant differences among them(P <0.05). There was no correlation between the expression of p27kip1 and Ki67 proteins in gastric polyp(rs=-0. 093, P >0. 05). Conclusion Detection of p27kip1 and Ki67 proteins in gastric polyp was very helpful in early diagnosis and prognosis of GC.
