CAJ | 학술논문

目的:探讨晚期糖基化终产物受体 (RAGE)在喉鳞状细胞癌(LSCC)中的表达与临床意义.方法:采用免疫组织化学SP法和RT-PCR法测定RAGE在37例LSCC中的表达,并以喉癌旁组织作为对照组,结合LSCC的临床和病理特征进行分析.结果:RAGE表达于细胞质与细胞膜中,在LSCC中的阳性率(51.4%)明显高于喉癌旁组织(25.0%)(P<0.05).在不同的病理分级中,RAGE的表达差异有统计学意义(P<0.01).结论:RAGE的表达与LSCC的生长、分化有关.
목적:탐토만기당기화종산물수체 (RAGE)재후린상세포암(LSCC)중적표체여림상의의.방법:채용면역조직화학SP법화RT-PCR법측정RAGE재37례LSCC중적표체,병이후암방조직작위대조조,결합LSCC적림상화병리특정진행분석.결과:RAGE표체우세포질여세포막중,재LSCC중적양성솔(51.4%)명현고우후암방조직(25.0%)(P<0.05).재불동적병리분급중,RAGE적표체차이유통계학의의(P<0.01).결론:RAGE적표체여LSCC적생장、분화유관.
Objective:To study the expression and clinical significance of receptor for advanced glycation end products (RAGE) in laryngeal squamous cell carcinoma (LSCC).Method:Immunohistochemical staining was used to detect the expressions of RAGE protein and semiquantitative method of reverse transcriptase polymerase chain reaction (RT-PCR) was used to analyze the expression level of RAGE mRNA in LSCC tissues and laryngeal normal tissues of 37 cases, respectively.Result:The mRNA and protein expression of RAGE was significantly higher in LSCC than that in normal laryngeal tissues(P<0.05), correlated with differentiation(P<0.01), but not with tumor stage and location(P>0.05).Conclusion:The expression levels of RAGE were significantly higher in LSCC than these in laryngeal normal tissues, RAGE is involved in differentiation of LSCC.