中华妇幼临床医学杂志（电子版）
中華婦幼臨床醫學雜誌（電子版）
중화부유림상의학잡지（전자판）
CHINESE JOURNAL OF OBSTETRICS & GYNECOLOGY AND PEDIATRICS(ELECTRONIC VERSION)
2012年
4期
389-391
,共3页
瘦素%CD34%微血管密度%宫颈癌%宫颈上皮内瘤变
瘦素%CD34%微血管密度%宮頸癌%宮頸上皮內瘤變
수소%CD34%미혈관밀도%궁경암%궁경상피내류변
leptin%CD34%microvessel density%cervical cancer%cervical intraepithelial neoplasia
目的 探讨瘦素在宫颈病变组织中的表达与临床病理学参数的关系.方法 选择2003年9月至2004年12月于同济医院确诊并接受治疗的142例宫颈病变患者为研究对象,并按照组织病理学结果将其分别纳入宫颈炎组(n=12)、宫颈上皮内瘤变(CIN)Ⅰ组(n=23)、CINⅡ组(n=25)、CINⅢ组(n=21)及宫颈癌组(n=58),分别测定各组瘦素表达强度及利用CD34标记宫颈组织中血管内皮细胞,并计算微血管密度(MVD)(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象本人的知情同意,并与之签署临床研究知情同意书).结果 瘦素在宫颈炎组、CIN各组及宫颈癌组的阳性表达率逐渐增加,且其余4组分别与宫颈炎组比较,差异均有统计学意义(P＜0.05).宫颈癌组瘦素和CD34表达与宫颈癌分化程度、淋巴结转移呈正相关关系(P＜0.05),而与患者年龄、临床分期无明显相关性(P＞0.05).宫颈癌组中MVD值随瘦素和CD34表达强度增强逐渐升高,且不同表达强度间比较,差异有统计学意义(P＜0.05).结论 瘦素是宫颈癌重要的血管生长因子,瘦素的异常表达与肿瘤的发生发展密切相关.
目的 探討瘦素在宮頸病變組織中的錶達與臨床病理學參數的關繫.方法 選擇2003年9月至2004年12月于同濟醫院確診併接受治療的142例宮頸病變患者為研究對象,併按照組織病理學結果將其分彆納入宮頸炎組(n=12)、宮頸上皮內瘤變(CIN)Ⅰ組(n=23)、CINⅡ組(n=25)、CINⅢ組(n=21)及宮頸癌組(n=58),分彆測定各組瘦素錶達彊度及利用CD34標記宮頸組織中血管內皮細胞,併計算微血管密度(MVD)(本研究遵循的程序符閤本院人體試驗委員會所製定的倫理學標準,得到該委員會批準,分組徵得受試對象本人的知情同意,併與之籤署臨床研究知情同意書).結果 瘦素在宮頸炎組、CIN各組及宮頸癌組的暘性錶達率逐漸增加,且其餘4組分彆與宮頸炎組比較,差異均有統計學意義(P＜0.05).宮頸癌組瘦素和CD34錶達與宮頸癌分化程度、淋巴結轉移呈正相關關繫(P＜0.05),而與患者年齡、臨床分期無明顯相關性(P＞0.05).宮頸癌組中MVD值隨瘦素和CD34錶達彊度增彊逐漸升高,且不同錶達彊度間比較,差異有統計學意義(P＜0.05).結論 瘦素是宮頸癌重要的血管生長因子,瘦素的異常錶達與腫瘤的髮生髮展密切相關.
목적 탐토수소재궁경병변조직중적표체여림상병이학삼수적관계.방법 선택2003년9월지2004년12월우동제의원학진병접수치료적142례궁경병변환자위연구대상,병안조조직병이학결과장기분별납입궁경염조(n=12)、궁경상피내류변(CIN)Ⅰ조(n=23)、CINⅡ조(n=25)、CINⅢ조(n=21)급궁경암조(n=58),분별측정각조수소표체강도급이용CD34표기궁경조직중혈관내피세포,병계산미혈관밀도(MVD)(본연구준순적정서부합본원인체시험위원회소제정적윤리학표준,득도해위원회비준,분조정득수시대상본인적지정동의,병여지첨서림상연구지정동의서).결과 수소재궁경염조、CIN각조급궁경암조적양성표체솔축점증가,차기여4조분별여궁경염조비교,차이균유통계학의의(P＜0.05).궁경암조수소화CD34표체여궁경암분화정도、림파결전이정정상관관계(P＜0.05),이여환자년령、림상분기무명현상관성(P＞0.05).궁경암조중MVD치수수소화CD34표체강도증강축점승고,차불동표체강도간비교,차이유통계학의의(P＜0.05).결론 수소시궁경암중요적혈관생장인자,수소적이상표체여종류적발생발전밀절상관.
Objective To evaluate the expression and clinical significance of leptin in cervical leison.Methods A totol of 142 women with cervical lesion were recruited in Tongji Hospital from September 2003 to December 2004.They were divided into chronic cervicitis group(n=12),cervical intraepithelial neoplasia (CIN) Ⅰ group( n =23 ),CIN Ⅱ group ( n =25 ),CIN Ⅲ group ( n =21 ) and cervical cancer group ( n =58 ) according to the histopathological results.Microvessels were immunohistochemical lablled with an antibody to CD34.Microscope analysis was used to evaluate microvessel density (MVD). The study protocal was approved by the Ethical Review Board of Investigation in Human Being of Xiangan Hospital. Informed consent was obtained from each patients.Results The expression of leptin was significantly higher in CIN and cervical cancer groups than that in chronic cervicitis group (P＜0.05).In addition,in cervical cancer group,there was no significant difference for leptin and CD34 expression in different age and clinical stages (P＞0.05),however,they were positively correlation with the degree of malignance and distant metastasis (P＜0.05).Conclusions Leptin is an important vascular endothelial growth factor (VEGF) in cervical cancer and local overexpression of leptin in cervical cancer may contribute to tumor progression by increasing angiogenesis and tumor growth.
