CAJ | 학술논문

目的探讨血管内皮生长因子(VEGF)和生存素(Survivin)在鼻咽癌组织中的表达情况和意义.方法应用免疫组化法检测VEGF和Survivin在80例鼻咽癌组织和24例鼻咽慢性炎性组织中的表达水平.结果 VEGF在鼻咽炎性组织中表达率为25.00%(6/80),在鼻咽癌组织中的表达率为75.76%(61/80),两者差异有统计学意义(P<0.01),Survivin在鼻咽炎性组织中表达率为16.67%(4/80),在鼻咽癌组织中的表达率为67.50%(54/80),两者差异有统计学意义(P<0.01).VEGF蛋白表达水平与TNM分期、T分期、淋巴结转移、远处转移有关(P<0.05),Survivin蛋白表达水平与TNM分期、淋巴结转移、远处转移有关(P<0.05).结论同时检测VEGF和Survivin有利于评估鼻咽癌的生物学行为和判断鼻咽癌预后.
목적 탐토혈관내피생장인자(VEGF)화생존소(Survivin)재비인암조직중적표체정황화의의.방법 응용면역조화법검측VEGF화Survivin재80례비인암조직화24례비인만성염성조직중적표체수평.결과 VEGF재비인염성조직중표체솔위25.00%(6/80),재비인암조직중적표체솔위75.76%(61/80),량자차이유통계학의의(P<0.01),Survivin재비인염성조직중표체솔위16.67%(4/80),재비인암조직중적표체솔위67.50%(54/80),량자차이유통계학의의(P<0.01).VEGF단백표체수평여TNM분기、T분기、림파결전이、원처전이유관(P<0.05),Survivin단백표체수평여TNM분기、림파결전이、원처전이유관(P<0.05).결론동시검측VEGF화Survivin유리우평고비인암적생물학행위화판단비인암예후.
Objective To explore the expression of vascular endothelial growth factor(VEGF) and Survivin in nasopharyngeal carcinoma.Methods Immunohistochemical method staining for the paraffin sections(SP method) were used to assess the expression of VECF and Survivin expression in 80 cases of nasopharyngeal carcinoma tissues and 24 cases of nasopharyngeal chronic inflammation tissues.Results The overexpression rate of VEGF protein was 75.76% (61/80) in nasopharyngeal carcinoma tissues,and 25.00% (6/80) in nasopharyngeal chronic inflammation tissues(P<0.01) ;The overexpression rate of Survivin protein was 67.50% (54/80) in nasopharyngeal carcinoma tissues,and 16.67% (4/80) in nasopharyngeal chronic inflammation tissues(P<0.01).The expression of VEGF was related to TNM stage,T stage,lymph node metastasis and distant metastasis (P<0.05) ,and there was a close relation between the expression of Survivin and TNM stage,T stage,lymph node metastasis and distant metastasis (P<0.05).Conclusion Detecting the expression levels of VEGF and Survivin proteins simultaneously in nasopharyngeal carcinoma had certain reference value for judging biological behavior and evaluating prognosis of patients with nasopharyngeal carcinoma.