中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
2期
124-127
,共4页
妊娠%中性粒细胞激活肽-78%睡眠呼吸暂停低通气综合征%血管内皮细胞钙黏蛋白
妊娠%中性粒細胞激活肽-78%睡眠呼吸暫停低通氣綜閤徵%血管內皮細胞鈣黏蛋白
임신%중성립세포격활태-78%수면호흡잠정저통기종합정%혈관내피세포개점단백
Pregnancy%Epithelial neutrophil-activing peptide-78%Sleep apnea syndromes%VE-cadherin hypopnea
目的 探讨妊娠合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与血清中性粒细胞激活肽-78(ENA-78)和血管内皮细胞钙黏蛋白(VE-cadherin)的相关性及其意义.方法 选择妊娠合并OSAHS患者102例,其中单纯OSAHS孕妇为60例(单纯OSAHS组),OSAHS合并高血压组孕妇42例(OSAHS合并高血压组)和正常妊娠组36例行标准多导睡眠呼吸监测系统监测记录呼吸暂停低通气指数(AHI)；并根据AHI分成轻度OSAHS组36例,中度OSAHS组34例和重度OSAHS组32例.采用酶联免疫(ELISA)法检测血清ENA-78和VE-cadherin.结果 OSAHS合并高血压组AHI、MAP、ENA-78和VE-cadherin浓度明显高于单纯OSAHS组(t值分别为13.46,11.65,12.47,13.36,P均＜0.01)和正常妊娠组(t值分别为16.72,15.31,16.35,16.73,P均＜0.01),单纯OSAHS组AHI、MAP、ENA-78和VE-cadherin浓度明显高于正常妊娠组(t值分别为8.92,9.27,10.24,10.23,P均＜0.01)；同时重度OSAHS患者的ENA-78和VE-cadherin浓度明显高于中度OSAHS组,中度组明显高于轻度组,差异均有统计学意义(P均＜0.01).其中OSAHS组患者AHI值与MAP、VE-cadherin、ENA-78呈正相关(r值分别为0.75,0.71,0.68,P均＜0.01)；OSAHS组患者ENA-78与MAP、VE-cadherin呈正相关(r值分别为0.64,0.67,P均＜0.01).结论 妊娠合并OSAHS患者病情与ENA-78、VE-cadherin浓度密切相关；妊娠合并OSAHS部分参与了妊娠期高血压疾病的病理过程.
目的 探討妊娠閤併阻塞性睡眠呼吸暫停低通氣綜閤徵(OSAHS)與血清中性粒細胞激活肽-78(ENA-78)和血管內皮細胞鈣黏蛋白(VE-cadherin)的相關性及其意義.方法 選擇妊娠閤併OSAHS患者102例,其中單純OSAHS孕婦為60例(單純OSAHS組),OSAHS閤併高血壓組孕婦42例(OSAHS閤併高血壓組)和正常妊娠組36例行標準多導睡眠呼吸鑑測繫統鑑測記錄呼吸暫停低通氣指數(AHI)；併根據AHI分成輕度OSAHS組36例,中度OSAHS組34例和重度OSAHS組32例.採用酶聯免疫(ELISA)法檢測血清ENA-78和VE-cadherin.結果 OSAHS閤併高血壓組AHI、MAP、ENA-78和VE-cadherin濃度明顯高于單純OSAHS組(t值分彆為13.46,11.65,12.47,13.36,P均＜0.01)和正常妊娠組(t值分彆為16.72,15.31,16.35,16.73,P均＜0.01),單純OSAHS組AHI、MAP、ENA-78和VE-cadherin濃度明顯高于正常妊娠組(t值分彆為8.92,9.27,10.24,10.23,P均＜0.01)；同時重度OSAHS患者的ENA-78和VE-cadherin濃度明顯高于中度OSAHS組,中度組明顯高于輕度組,差異均有統計學意義(P均＜0.01).其中OSAHS組患者AHI值與MAP、VE-cadherin、ENA-78呈正相關(r值分彆為0.75,0.71,0.68,P均＜0.01)；OSAHS組患者ENA-78與MAP、VE-cadherin呈正相關(r值分彆為0.64,0.67,P均＜0.01).結論 妊娠閤併OSAHS患者病情與ENA-78、VE-cadherin濃度密切相關；妊娠閤併OSAHS部分參與瞭妊娠期高血壓疾病的病理過程.
목적 탐토임신합병조새성수면호흡잠정저통기종합정(OSAHS)여혈청중성립세포격활태-78(ENA-78)화혈관내피세포개점단백(VE-cadherin)적상관성급기의의.방법 선택임신합병OSAHS환자102례,기중단순OSAHS잉부위60례(단순OSAHS조),OSAHS합병고혈압조잉부42례(OSAHS합병고혈압조)화정상임신조36례행표준다도수면호흡감측계통감측기록호흡잠정저통기지수(AHI)；병근거AHI분성경도OSAHS조36례,중도OSAHS조34례화중도OSAHS조32례.채용매련면역(ELISA)법검측혈청ENA-78화VE-cadherin.결과 OSAHS합병고혈압조AHI、MAP、ENA-78화VE-cadherin농도명현고우단순OSAHS조(t치분별위13.46,11.65,12.47,13.36,P균＜0.01)화정상임신조(t치분별위16.72,15.31,16.35,16.73,P균＜0.01),단순OSAHS조AHI、MAP、ENA-78화VE-cadherin농도명현고우정상임신조(t치분별위8.92,9.27,10.24,10.23,P균＜0.01)；동시중도OSAHS환자적ENA-78화VE-cadherin농도명현고우중도OSAHS조,중도조명현고우경도조,차이균유통계학의의(P균＜0.01).기중OSAHS조환자AHI치여MAP、VE-cadherin、ENA-78정정상관(r치분별위0.75,0.71,0.68,P균＜0.01)；OSAHS조환자ENA-78여MAP、VE-cadherin정정상관(r치분별위0.64,0.67,P균＜0.01).결론 임신합병OSAHS환자병정여ENA-78、VE-cadherin농도밀절상관；임신합병OSAHS부분삼여료임신기고혈압질병적병리과정.
Objective To investigate the possible correlation between obstructive sleep apnea hypopnea syndrome(OSAHS)and serum epithelial neutrophil-activing peptide-78(ENA-78)and VE-cadherin in pregnant patients.Methods One hundred and two pregnant women combined with OSAHS,42 of which were with hypertension,and 36 healthy pregnant women were underwent polysomnography(PSG),and their apnea hypopnea index(AHI)was recorded.Based on the apnea hypopnea index(AHI),they were divided into mild OSAHS group(36 patients),moderate OSAHS group(34 patients)and severe OSAHS group(32 patients)Serum ENA-78 and VE-cadhefin levels were detected by enzyme-linked immunosorbent assay(ELISA),and mean arterial pressure(MAP)was measured simultaneously.Results The values of AHI,MAP,ENA-78 and VE-cadherin in OSAHS with hypertension were significantly higher than those of OSAHS only group(t =13.46,11.65,12.47,13.36,all P ＜ 0.01)and the control group(t =16.72,15.31,16.35,16.73,all P ＜ 0.01).The levels of serum ENA-78 and VE-cadherin were gradually significantly decreased in the order of severe OSAHS group,moderate OSAHS group and mild OSAHS group(P ＜0.01).The AHI of OSAHS group was significantly correlated with MAP,VE-cadherin,ENA-78(r =0.75,0.71,0.68,all P ＜ 0.01).ENA-78 of OSAHS group were positively correlated with MAP and VE-cadherin(r =0.64,0.67,all P ＜ 0.01).Conclusions The condition OSAHS in pregnant patients is closely related to the levels of ENA-78 and VE-cadherin.Pregnancy combined with OSAHS may take part in the pathological process of hypertensive disorder complicating pregnancy.
