中国医药
中國醫藥
중국의약
CHINA MEDICINE
2009年
6期
427-428
,共2页
非小细胞肺癌%上皮型钙黏蛋白%免疫组织化学
非小細胞肺癌%上皮型鈣黏蛋白%免疫組織化學
비소세포폐암%상피형개점단백%면역조직화학
Non-small cell lung cancer%E-cadherin%lmmunohistochemistry
目的 通过上皮型钙黏蛋白(E-cad)在人非小细胞肺癌组织中表达的检测,探讨其与肺癌临床病理和预后的关系.方法 采用免疫组织化学SP法检测62例非小细胞肺癌组织中E-cad的表达,并取10例炎性假瘤患者作为对照.结果 62例非小细胞肺癌组织中E-cad阳性表达率为56.45%(35/62),其阳性表达率与患者的性别、年龄、组织学类型及肿瘤大小差异无统计学意义,随着肺癌分化程度降低而呈下降趋势.E-cad在是否有肺癌淋巴结转移及不同TNM分期间差异均有统计学意义.结论 E-cad表达下调在肿瘤侵袭转移中起重要作用,这个因子可成为潜在的判定因素.检测E-cad的表达对非小细胞肺癌患者临床病情评估、预后判断及治疗方法选择具有一定指导意义.
目的 通過上皮型鈣黏蛋白(E-cad)在人非小細胞肺癌組織中錶達的檢測,探討其與肺癌臨床病理和預後的關繫.方法 採用免疫組織化學SP法檢測62例非小細胞肺癌組織中E-cad的錶達,併取10例炎性假瘤患者作為對照.結果 62例非小細胞肺癌組織中E-cad暘性錶達率為56.45%(35/62),其暘性錶達率與患者的性彆、年齡、組織學類型及腫瘤大小差異無統計學意義,隨著肺癌分化程度降低而呈下降趨勢.E-cad在是否有肺癌淋巴結轉移及不同TNM分期間差異均有統計學意義.結論 E-cad錶達下調在腫瘤侵襲轉移中起重要作用,這箇因子可成為潛在的判定因素.檢測E-cad的錶達對非小細胞肺癌患者臨床病情評估、預後判斷及治療方法選擇具有一定指導意義.
목적 통과상피형개점단백(E-cad)재인비소세포폐암조직중표체적검측,탐토기여폐암림상병리화예후적관계.방법 채용면역조직화학SP법검측62례비소세포폐암조직중E-cad적표체,병취10례염성가류환자작위대조.결과 62례비소세포폐암조직중E-cad양성표체솔위56.45%(35/62),기양성표체솔여환자적성별、년령、조직학류형급종류대소차이무통계학의의,수착폐암분화정도강저이정하강추세.E-cad재시부유폐암림파결전이급불동TNM분기간차이균유통계학의의.결론 E-cad표체하조재종류침습전이중기중요작용,저개인자가성위잠재적판정인소.검측E-cad적표체대비소세포폐암환자림상병정평고、예후판단급치료방법선택구유일정지도의의.
Objective To investigate the relationship between the different expression effect of E-cadherin (E-cad) in non-small cell lung cancer and the clinical pathological characteristics, illness prognosis and biological behaviors of cancer. Methods The immunohistochemical technique SP method was used to examine protein expression of level of E-cadherin in 62 patients with non-small cell lung cancer, and 10 cases of inflammatory pseudotumor as control. Results The total positive rates of E-cad protein was 56.45% in non-small cell lung cancer respectively. No relationship was observed between of the positive expression of the above three protein and sex, age, histopatholigy and the size of tumor. The posiwe rate of E-cad protein expression was decreased with the level of differentation of lung cacer. The positive rate of E-cad protein expression was significant in the clinical stage and lymph node metastasis of non-small cell lung cancer. Conclusions The protein expression level of E-cad may accelerate significantly to tumor invasion and metastasis. Measuring of the expression E-cad has a significant guiding value for clinical assessment, prognosis and choose of a suitable therapy measure for non-small cell lung cancer.
