CAJ | 학술논문

目的探讨利用傅里叶变换红外(FTIR)光谱技术鉴别乳腺癌和乳腺良性肿物的可行性.方法联合运用衰减全反射(ATR)探头与中红外光纤、FTIR光谱分析仪,测定26例乳腺癌患者和34例乳腺良性肿物患者体表的FTIR光谱,比较两组光谱各个谱带的峰位(P)、相对峰强(I)及半高宽指标(F),总结乳腺癌体表光谱的特征.结果与乳腺良性肿物体表光谱比较,乳腺癌体表光谱中(1)蛋白质酰胺Ⅱ带P1546发生明显地红移(向低波数移动,P＜0.05);(2)与核酸相关的相对峰强11256/I1460(P＜0.05)明显升高;(3)与C-H或C-O-H的变角振动的谱带峰位P1303发生明显地红移(向低波数移动)(P＜0.05).结论乳腺癌体表FTIR光谱与乳腺良性肿物体表的光谱比较,在蛋白质、核酸和脂类相关谱带均有明显差异.
목적 탐토이용부리협변환홍외(FTIR)광보기술감별유선암화유선량성종물적가행성.방법 연합운용쇠감전반사(ATR)탐두여중홍외광섬、FTIR광보분석의,측정26례유선암환자화34례유선량성종물환자체표적FTIR광보,비교량조광보각개보대적봉위(P)、상대봉강(I)급반고관지표(F),총결유선암체표광보적특정.결과 여유선량성종물체표광보비교,유선암체표광보중(1)단백질선알Ⅱ대P1546발생명현지홍이(향저파수이동,P＜0.05);(2)여핵산상관적상대봉강11256/I1460(P＜0.05)명현승고;(3)여C-H혹C-O-H적변각진동적보대봉위P1303발생명현지홍이(향저파수이동)(P＜0.05).결론 유선암체표FTIR광보여유선량성종물체표적광보비교,재단백질、핵산화지류상관보대균유명현차이.
Objective To explore the feasibility of superficially differentiating breast cancer from the benign fourier transform infrared ( FTIR) spectroscopy. Methods Twenty-six cases of breast cancer and 34 cases of the benign were examined superficially by FTIR spectroscopy. For each FTIR spectrum,the peak positions (P), relative intensity (I) and full width at half maximum ( F) of the band were recorded and the relative intensity ratios were calculated. Results In the group of breast cancer, both the peaks of 1546 cm-1 and 1303 cm-1 shifted toward lower wave number (P ＜0. 05), as compared to those of the benign group. The relative intensity ratio of I1256/I1460) was increased significantly (P ＜ 0. 05). Conclusion There existed many significant differences in FTIR spectra between malignant and benign breast masses.