CAJ | 학술논문

目的探讨肺鳞癌组织中淋巴管密度和纵隔淋巴结转移的关系.方法肺鳞癌纵隔淋巴结无转移组22例,肺鳞癌纵隔淋巴结转移组18例,肺炎性假瘤组10例.用LYVE-1/CD34免疫组化双染色法区分淋巴管和血管并观察淋巴管内皮透明质酸受体-1(LYVE-1)蛋白表达的情况,并与手术纵隔淋巴结清扫病理结果相比较.结果肺鳞癌组织周边部淋巴管密度远大于内部和炎性假瘤组织.肺鳞癌组织内部淋巴管和炎性假瘤组织淋巴管密度相似.肺鳞癌组织周边部淋巴管密度纵隔淋巴结转移组大于无纵隔淋巴结转移组.肺鳞癌组织内部淋巴管密度纵隔淋巴结转移组和无纵隔淋巴结转移组相似.结论肺鳞癌组织淋巴管生成主要在周边部,肺鳞癌细胞主要经过原发灶周边部增生的淋巴管转移至纵隔淋巴结.
목적탐토폐린암조직중림파관밀도화종격림파결전이적관계.방법폐린암종격림파결무전이조22례,폐린암종격림파결전이조18례,폐염성가류조10례.용LYVE-1/CD34면역조화쌍염색법구분림파관화혈관병관찰림파관내피투명질산수체-1(LYVE-1)단백표체적정황,병여수술종격림파결청소병리결과상비교.결과폐린암조직주변부림파관밀도원대우내부화염성가류조직.폐린암조직내부림파관화염성가류조직림파관밀도상사.폐린암조직주변부림파관밀도종격림파결전이조대우무종격림파결전이조.폐린암조직내부림파관밀도종격림파결전이조화무종격림파결전이조상사.결론폐린암조직림파관생성주요재주변부,폐린암세포주요경과원발조주변부증생적림파관전이지종격림파결.
Objective：To investigate the relationship between the mediastinal lymph node metastasis and the distribution and density of lymphoducts in pulmonary squamous cell carcinoma. Methods：In 18 cases of pulmonary squamous cell carcinoma having mediastinal lymph node metastasis, 22 cases of pulmonary squa mous cell carcinoma having no mediastinal lymph node metastasis and 10 cases of pulmonary poroma, double immunohistochemical staining for LYVE-1/CD34 was performed to distinguish lymphoducts from blood vessels,and observe the lymphatic vessel endothelial HA receptor-1(LYVE-1) manifestation, then the density of lymphoducts was compared with the pathological report of mediastinal lymph node dissection. Results：The density of lymphatic vessels was elevated in the perimeter of the pulmonary squamous cell carcinoma tissue rela tive to the interior and the pulmonary inflammatory pseudotumor. The density of lymphatic vessels in the interior of the pulmonary squamous cell carcinoma tissue was similar to that of pulmonary inflammatory pseudotumor. The density of lymphatic vessels in the perimeter of the pulmonary squamous cell carcinoma with mediastinal lymph node metastasis was higher than that of the pulmonary squamous cell carcinoma with no mediastinal lymph node metastasis.The density of lymphatic vessels in the interior of the pulmonary squamous cell carcinoma with mediastinal lymph node metastasis was similar to that of the pulmonary squamous cell carcinoma with no mediastinal lymph node metastasis. Conclusions：The formation of lymphoducts is mainly in the perimeter of the pulmonary squamous cell carcinoma tissue.Tumor cells of the pulmonary squamous cell carcinoma mainly disseminate to the mediastinal lymph nodes through the roliferative lymphoducts in the perimeter of the pulmonary squamous cell carcinoma.