CAJ | 학술논문

目的：观察不稳定型心绞痛血浆P选择素变化及变化在调脂干预对急性冠状动脉(冠脉)事件的冠脉粥样病变炎症反应的影响。方法：用酶联免疫吸附法及硝酸还原酶比色法测定30例健康对照组和62例冠心病不稳定型心绞痛患者应用辛伐他汀治疗前后的血浆P选择素、氧化修饰低密度脂蛋白(OXLDL)和血清一氧化氮(NO)水平。结果：不稳定性心绞痛组血浆P选择素、OXLDL水平较对照组明显增高，血清NO水平明显减低；血浆P选择素水平与血浆OXLDL水平呈显著正相关,与血清NO水平显著负相关；辛伐他汀治疗6周后不稳定型心绞痛组血浆P选择素、OXLDL水平明显降低，血清NO水平明显回升。结论：(1)急性冠脉事件的确存在着冠脉粥样病变的炎症反应；(2)冠脉粥样病变炎症反应与脂质过氧化及内皮细胞功能失常共同参与了急性冠脉事件的发生发展过程；(3)调脂干预可阻断冠脉粥样病变的炎症反应，阻止病程的进展。
목적：관찰불은정형심교통혈장P선택소변화급변화재조지간예대급성관상동맥(관맥)사건적관맥죽양병변염증반응적영향。방법：용매련면역흡부법급초산환원매비색법측정30례건강대조조화62례관심병불은정형심교통환자응용신벌타정치료전후적혈장P선택소、양화수식저밀도지단백(OXLDL)화혈청일양화담(NO)수평。결과：불은정성심교통조혈장P선택소、OXLDL수평교대조조명현증고，혈청NO수평명현감저；혈장P선택소수평여혈장OXLDL수평정현저정상관,여혈청NO수평현저부상관；신벌타정치료6주후불은정형심교통조혈장P선택소、OXLDL수평명현강저，혈청NO수평명현회승。결론：(1)급성관맥사건적학존재착관맥죽양병변적염증반응；(2)관맥죽양병변염증반응여지질과양화급내피세포공능실상공동삼여료급성관맥사건적발생발전과정；(3)조지간예가조단관맥죽양병변적염증반응，조지병정적진전。
Objective:To study the relationship between plasma Pselectin and coronary arteriosclerotic lesions and the effects of intervention lipid lowering in the patients with unstable angina pectoris.Methods:The plasma Pselectin and oxidized low density lipoprotein (OXLDL) were measured by enzymelinked immunosorbent assay (ELISA) and serum nitric oxide (NO) was measured by colorimetric analysis method before and after treatment with simvastatin in 62 patients with unstable angina pectoris and 30 healthy controls.Results:(1) The patients with unstable angina pectoris had higher levels of plasma Pselectin and OXLDL,lower levels of serum NO compared with those of control subjects.(2) A direct positive correlation was observed between plasma Pselectin and OXLDL levels and a direct negative correlation between plasma Pselectin and NO levels in patients with unstable angina pectoris.(3) Administration of simvastatin (20 mg/d for 6 weeks) to patients with unstable angina pectoris significantly reduced plasma Pselection and OXLDL levels and significantly elevated serum NO level.Conclusions:The patients with unstable angina pectoris do have inflammatory reaction due to coronary arterisclerotic lesions.The development of the disease is closely related to plasma Pselection,OXLDL and serum NO levels,and it can be blocked by intervention therapy for lipid lowering.