CAJ | 학술논문

背景:聚吡咯因其特殊的电学性质被广泛应用于生物医学工程领域.近20年来,在组织工程领域有越来越多的关于其作为施电细胞组织培养基底用于组织和细胞再生方面的研究.目的:全面了解聚吡咯类生物材料在不同类组织工程中的应用,为今后该类材料在组织工程方面的进一步研究以及新型医学生物材料的研发提供思路.方法:以"polypyrrole"为检索词,应用计算机检索Pubmed数据库,中国生物医学文献数据库1990/2010发表的相关文章.纳入与聚吡咯组织工程应用密切相关的文献,排除重复性研究.结果与结论:共检索到762篇文献,排除无关重复的文献,保留51篇文献进行综述.目前聚吡咯类生物材料主要用于神经组织工程、心血管组织工程、骨及肌肉组织工程、皮肤组织工程等方面.这类生物材料由于其多功能性以及良好的生物相容性,对于未来新型组织工程材料的研发以及组织工程的进一步研究具有重大的价值.
배경:취필각인기특수적전학성질피엄범응용우생물의학공정영역.근20년래,재조직공정영역유월래월다적관우기작위시전세포조직배양기저용우조직화세포재생방면적연구.목적:전면료해취필각류생물재료재불동류조직공정중적응용,위금후해류재료재조직공정방면적진일보연구이급신형의학생물재료적연발제공사로.방법:이"polypyrrole"위검색사,응용계산궤검색Pubmed수거고,중국생물의학문헌수거고1990/2010발표적상관문장.납입여취필각조직공정응용밀절상관적문헌,배제중복성연구.결과여결론:공검색도762편문헌,배제무관중복적문헌,보류51편문헌진행종술.목전취필각류생물재료주요용우신경조직공정、심혈관조직공정、골급기육조직공정、피부조직공정등방면.저류생물재료유우기다공능성이급량호적생물상용성,대우미래신형조직공정재료적연발이급조직공정적진일보연구구유중대적개치.
BACKGROUND: Polypyrrole (PPy) has been widely applied in biomedical fields due to its special electronic property. Past 20 years, there are an increasing number of studies on the application of PPy as a potentially electrically addressable tissue/cell support substrate for tissue/cell regeneration.OBJECTIVE: To overall review the application of PPy in tissue engineering field, and to provide a new approach for the research and development of medical biomaterials.METHODS: Pubmed and Chinese biomedicine literature database were searched using key word of "polypyrrole" for documents published between 1990 and 2010. Literatures related to application of PPy in tissue engineering field were included, and the repetitive articles were excluded.RESULTS AND CONCLUSION: Totally 762 papers were searched by computer, according to the inclusive and exclusive criteria, 51 literature were reviewed. Currently, PPy has been widely used in the fields of cardiovascular tissue engineering, bone and muscle tissue engineering, as well as skin tissue engineering. Application of PPy and PPy-based biomaterials hold great potential in development of novel biomedical materials applied in tissue engineering due to their versatile functionality and superior biocompatibility.