中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2011年
6期
574-582
,共9页
加替沙星滴眼液%细菌性结膜炎%细菌敏感率
加替沙星滴眼液%細菌性結膜炎%細菌敏感率
가체사성적안액%세균성결막염%세균민감솔
Gatifloxacin eye drops%Bacterial conjunctivitis%Antibacterial activity
目的 探讨加替沙星滴眼液治疗细菌性结膜炎的临床效果.方法 加替沙星组和氧氟沙星组各为120例,合计240例.采用计算机编程随机法,随机双盲对照试验.患者的纳入应能满足所有入选及排除标准,随机分为加替沙星组和氧氟沙星组,分别给予加替沙星滴眼液和相同浓度对照药氧氟沙星滴眼液,疗程7～14天.加替沙星滴眼液组:每日5次,每次1～2滴,滴入结膜囊内,氧氟沙星滴眼液组:每日5次,每次1～2滴,滴入结膜囊内,随诊观察.结果 本研究共分离临床敛病菌67株,其对加替沙星、氧氟沙星、左氧氟沙星和环丙沙星的敏感率分别为98.51%、85.07%、95.52%、78.79%.表明加替沙星的细菌敏感率最高,与氧氟沙星比较,差异有统计学意义.加替沙星滴眼液治疗细菌性结膜炎的疗效不低于氧氟沙星滴眼液.结论 结果表明,加替沙星滴眼液抗菌谱广、抗菌活性强,与氧氟沙星滴眼液疗效相当,安全性好,适于作为细菌性结膜炎的治疗用药.同时对革兰阳性菌和革兰阴性菌感染的眼表疾病,都有一定的治疗效果.
目的 探討加替沙星滴眼液治療細菌性結膜炎的臨床效果.方法 加替沙星組和氧氟沙星組各為120例,閤計240例.採用計算機編程隨機法,隨機雙盲對照試驗.患者的納入應能滿足所有入選及排除標準,隨機分為加替沙星組和氧氟沙星組,分彆給予加替沙星滴眼液和相同濃度對照藥氧氟沙星滴眼液,療程7～14天.加替沙星滴眼液組:每日5次,每次1～2滴,滴入結膜囊內,氧氟沙星滴眼液組:每日5次,每次1～2滴,滴入結膜囊內,隨診觀察.結果 本研究共分離臨床斂病菌67株,其對加替沙星、氧氟沙星、左氧氟沙星和環丙沙星的敏感率分彆為98.51%、85.07%、95.52%、78.79%.錶明加替沙星的細菌敏感率最高,與氧氟沙星比較,差異有統計學意義.加替沙星滴眼液治療細菌性結膜炎的療效不低于氧氟沙星滴眼液.結論 結果錶明,加替沙星滴眼液抗菌譜廣、抗菌活性彊,與氧氟沙星滴眼液療效相噹,安全性好,適于作為細菌性結膜炎的治療用藥.同時對革蘭暘性菌和革蘭陰性菌感染的眼錶疾病,都有一定的治療效果.
목적 탐토가체사성적안액치료세균성결막염적림상효과.방법 가체사성조화양불사성조각위120례,합계240례.채용계산궤편정수궤법,수궤쌍맹대조시험.환자적납입응능만족소유입선급배제표준,수궤분위가체사성조화양불사성조,분별급여가체사성적안액화상동농도대조약양불사성적안액,료정7～14천.가체사성적안액조:매일5차,매차1～2적,적입결막낭내,양불사성적안액조:매일5차,매차1～2적,적입결막낭내,수진관찰.결과 본연구공분리림상렴병균67주,기대가체사성、양불사성、좌양불사성화배병사성적민감솔분별위98.51%、85.07%、95.52%、78.79%.표명가체사성적세균민감솔최고,여양불사성비교,차이유통계학의의.가체사성적안액치료세균성결막염적료효불저우양불사성적안액.결론 결과표명,가체사성적안액항균보엄、항균활성강,여양불사성적안액료효상당,안전성호,괄우작위세균성결막염적치료용약.동시대혁란양성균화혁란음성균감염적안표질병,도유일정적치료효과.
Objective To study the clinical efficacy of gatifloxacin eye drops for bacterial conjunctivitis.Methods A total of 240 cases that diagnosed as bacterial conjunctivitis were randomly divided into test group (gatifloxacin) and control group (floxacin).A random double-blind and paralled study was conducted on 120 cases with gatifloxacin and floxacin eye drops for bacterial conjunctivitis.The drug delivery into conjunctival sac was performed at 7-14 days (one-two drops per time, five times per day).Results Sixty-seven clinical common pathogenic bacteria were separated from the study.The antibacterial activity of gatifloxacin,floxacin, levofloxacin, ciprofloxacin was 98.51%, 85.07%, 95.52%, and 78.79% respectively.The antibacterial activity of gatifloxacin was the highest, and the statistic difference between gatifloxacin and floxacin was found.The effect of gatifloxacin eye drops was not worse than floxacin eye drops.Conclusions The gatifloxacin eye drops has characteristics with broad spectrum, powerfull antibacterial activity.The linical effect of gatifloxacin eye drops is the same with floxacin eye drops.Gatifloxacin eye drops are safe and can be used to treat bacterial conjunctivitis.It has comparatively theropic value of ocular surface disease with Gram-positive bacterial and Gram-negetive bacterial.
