CAJ | 학술논문

目的探讨激光消融活体兔肝的超声表现及影响因素.方法用Echolaser集成激光介入超声系统消融正常兔肝,观察消融灶坏死程度、病理改变及解剖表现.结果消融灶呈类椭圆形,二维表现为中心规则强回声及周边稍强回声区,后方有轻度声衰减.超声造影显示消融灶呈"充盈缺损区".解剖后,肉眼观消融灶中间为碎渣样碳化区,周边为褐白色样坏死区.HE染色显示消融灶中心呈"空洞样"无染色剂浸染区,周边呈不规则无核红染区,外围可见浸润的炎性细胞.不同功率及时间对消融效果及消融范围有影响且消融灶的大小与功率和时间呈正相关;3 w 10 min组和5 W 6 min组消融范围稳定、可导致消融区组织的完全坏死且两组间的消融范围差异有统计学意义(t=6.78,P<0.05).结论激光消融对活体兔肝能造成快速、精准、有效、安全的凝固性坏死,消融灶的大小与功率和时间呈正相关.
목적 탐토격광소융활체토간적초성표현급영향인소.방법 용Echolaser집성격광개입초성계통소융정상토간,관찰소융조배사정도、병리개변급해부표현.결과 소융조정류타원형,이유표현위중심규칙강회성급주변초강회성구,후방유경도성쇠감.초성조영현시소융조정"충영결손구".해부후,육안관소융조중간위쇄사양탄화구,주변위갈백색양배사구.HE염색현시소융조중심정"공동양"무염색제침염구,주변정불규칙무핵홍염구,외위가견침윤적염성세포.불동공솔급시간대소융효과급소융범위유영향차소융조적대소여공솔화시간정정상관;3 w 10 min조화5 W 6 min조소융범위은정、가도치소융구조직적완전배사차량조간적소융범위차이유통계학의의(t=6.78,P<0.05).결론 격광소융대활체토간능조성쾌속、정준、유효、안전적응고성배사,소융조적대소여공솔화시간정정상관.
Objective To explore the ultrasound performance and related factors on the role of normal living rabbit's liver by laser ablation. Methods The rabbit's liver tissue were ablated by Echolaser integrated laser interventional ultrasound system, and the necrosis of the lesion and performance of pathology and anatomy were observed. Results The outline of the lesion was ellipse like. The two-dimensional US showed regular hyperecho area in the center, mild strong echo in the peripheral and mild attenuation backward. Contrast enhanced ultrasound (CEUS) showed a "filling defect" of contrast media in the ablated area. After dissection, the center of the lesion was slag-like carbon, the peripheral was necrosis area; HE staining showed: the center of the lesion was cavity like and dye-free,peripheral area was irregular red staining, the surrounding area was infiltrative inflammatory cells. Different power and time leaded to differences of the ablative effect and lesion size:the more power and time,the bigger of the ablative size. The ablative effect and lesion size was stable in 3 W 10 min and 5 W 6 min groups and caused the complete necrosis of the zone, there existed statistical differences among the two groups. Conclusions Laser ablation can cause fast, precise, effective and safe necrosis of the liver tissue, and the more power and time, the bigger of the ablative size.