中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2008年
10期
689-691
,共3页
徐丽敏%韩静倩%赵宏丽%李晓莉
徐麗敏%韓靜倩%趙宏麗%李曉莉
서려민%한정천%조굉려%리효리
银屑病%抗原,CD14%Toll样受体4%NF-kB
銀屑病%抗原,CD14%Toll樣受體4%NF-kB
은설병%항원,CD14%Toll양수체4%NF-kB
Psoriasis%Antigens,CD14%Toll-like receptor 4%NF-kappa B
目的 探讨银屑病患者外周血白细胞mCD14、TLR4和NF-kB表达意义. 方法 采用流式细胞仪榆测银屑病患者32例和正常人29例外周血白细胞mCD14、TLR4和NF-kB的表达. 结果 32例银屑病组外周血白细胞表面mCD14表达5.454±2.78,对照组3.937±1.964.差异有统计学意义(P<0.05).TLR4表达,银屑病组17.641±18.120,对照组7.527±8.574,差异有统计学意义(P<0.01).银屑病组外周血总白细胞活化NF-kB的表达为63.538±8.650,对照组62.236±6.72,差异无统计学意义(P>0.05). 结论 银屑病患者中存在mCD14、TLR4表达异常,提示内毒素信号传导通路的异常激活也是感染诱发银屑病的病因之一.
目的 探討銀屑病患者外週血白細胞mCD14、TLR4和NF-kB錶達意義. 方法 採用流式細胞儀榆測銀屑病患者32例和正常人29例外週血白細胞mCD14、TLR4和NF-kB的錶達. 結果 32例銀屑病組外週血白細胞錶麵mCD14錶達5.454±2.78,對照組3.937±1.964.差異有統計學意義(P<0.05).TLR4錶達,銀屑病組17.641±18.120,對照組7.527±8.574,差異有統計學意義(P<0.01).銀屑病組外週血總白細胞活化NF-kB的錶達為63.538±8.650,對照組62.236±6.72,差異無統計學意義(P>0.05). 結論 銀屑病患者中存在mCD14、TLR4錶達異常,提示內毒素信號傳導通路的異常激活也是感染誘髮銀屑病的病因之一.
목적 탐토은설병환자외주혈백세포mCD14、TLR4화NF-kB표체의의. 방법 채용류식세포의유측은설병환자32례화정상인29예외주혈백세포mCD14、TLR4화NF-kB적표체. 결과 32례은설병조외주혈백세포표면mCD14표체5.454±2.78,대조조3.937±1.964.차이유통계학의의(P<0.05).TLR4표체,은설병조17.641±18.120,대조조7.527±8.574,차이유통계학의의(P<0.01).은설병조외주혈총백세포활화NF-kB적표체위63.538±8.650,대조조62.236±6.72,차이무통계학의의(P>0.05). 결론 은설병환자중존재mCD14、TLR4표체이상,제시내독소신호전도통로적이상격활야시감염유발은설병적병인지일.
Objective To investigate the expression of membrane CD14 (mCD14), Toll-like receptor (TLR4) and nuclear factor-kappa B (NF-kB) in peripheral blood ieukocytes from patients with psoriasis vulgaris (PV). Methods Blood samples were obtained from 29 normal controls and 32 patients with PV. Patient cohort consisted of 19 males and 13 females, with an average age of 30.28 ±13.11 years, disease duration of 8.21±10.21 years, and PASI score of 21.19±5.85. Flow cytometry was used to measure the expression of mCD14, TLR4 and activated NF-kB in peripheral blood leukocytes in these subjects. Results The expressions of mCD14 and TLR4 in peripheral blood leukocytes were significantly higher in patients than in the normal controls (5.454±2.78 vs 3.937±1.964, P < 0.05; 17.641±18.120 vs 7.527±8.574, P <0.01 ). Although the expression of activated NF-kB in total blood leukocytes in patients was higher than that in normal controls, no statistical difference was noticed (63.538±8.650 vs 62.236±6.72, P > 0.05). Conclusion There is an abnormal expression of mCD14 and TLR4 in patients with PV, suggesting that the abnormal activation of endotoxin signal transduction pathway may exert a role in the induction of psoriasis.
