中国医药
中國醫藥
중국의약
CHINA MEDICINE
2011年
8期
949-950
,共2页
孙锡波%陈澎%高茜%李炳选
孫錫波%陳澎%高茜%李炳選
손석파%진팽%고천%리병선
一氧化碳中毒%迟发性脑病%依达拉奉%银杏叶提取物%高压氧
一氧化碳中毒%遲髮性腦病%依達拉奉%銀杏葉提取物%高壓氧
일양화탄중독%지발성뇌병%의체랍봉%은행협제취물%고압양
Carbon monoxide poisoning%Delayed encephalopathy%Edaravone%Extract of gingo biloba leaves%Hyperbaric oxygen
目的 探讨依达拉奉、银杏叶提取物注射液联合高压氧治疗一氧化碳中毒后迟发性脑病(DEACMP)的临床疗效.方法 将2007年1月至2010年6月我院64例DEACMP患者完全随机分为治疗组及对照组,各32例.对照组给予高压氧等常规治疗,治疗30 d.治疗组在高压氧等常规治疗基础上加用依达拉奉30 mg/次,2次/d静脉滴注,连用14 d;银杏叶提取物注射液70 mg,加入0.9%氯化钠注射液250 ml静脉滴注,1次/d,连用30 d.治疗前后均用长谷川智能量表(HDS)检测智能评分,并统计2组治疗总有效率.结果 治疗组有效28例,总有效率为87.5%;对照组有效20例,总有效率为62.5%,2组疗效比较差异有统计学意义(x2=5.33,P＜0.05),治疗组治疗后HDS评分明显高于对照组[治疗后15 d:(13.6±2.3)分比(9.4±2.1)分,P＜0.05;治疗后30 d:(19.3±2.1)分比(12.8±2.7)分,P＜0.01].结论 依达拉奉、银杏叶提取物注射液联合高压氧治疗DEACMP疗效好,值得临床推广.
目的 探討依達拉奉、銀杏葉提取物註射液聯閤高壓氧治療一氧化碳中毒後遲髮性腦病(DEACMP)的臨床療效.方法 將2007年1月至2010年6月我院64例DEACMP患者完全隨機分為治療組及對照組,各32例.對照組給予高壓氧等常規治療,治療30 d.治療組在高壓氧等常規治療基礎上加用依達拉奉30 mg/次,2次/d靜脈滴註,連用14 d;銀杏葉提取物註射液70 mg,加入0.9%氯化鈉註射液250 ml靜脈滴註,1次/d,連用30 d.治療前後均用長穀川智能量錶(HDS)檢測智能評分,併統計2組治療總有效率.結果 治療組有效28例,總有效率為87.5%;對照組有效20例,總有效率為62.5%,2組療效比較差異有統計學意義(x2=5.33,P＜0.05),治療組治療後HDS評分明顯高于對照組[治療後15 d:(13.6±2.3)分比(9.4±2.1)分,P＜0.05;治療後30 d:(19.3±2.1)分比(12.8±2.7)分,P＜0.01].結論 依達拉奉、銀杏葉提取物註射液聯閤高壓氧治療DEACMP療效好,值得臨床推廣.
목적 탐토의체랍봉、은행협제취물주사액연합고압양치료일양화탄중독후지발성뇌병(DEACMP)적림상료효.방법 장2007년1월지2010년6월아원64례DEACMP환자완전수궤분위치료조급대조조,각32례.대조조급여고압양등상규치료,치료30 d.치료조재고압양등상규치료기출상가용의체랍봉30 mg/차,2차/d정맥적주,련용14 d;은행협제취물주사액70 mg,가입0.9%록화납주사액250 ml정맥적주,1차/d,련용30 d.치료전후균용장곡천지능량표(HDS)검측지능평분,병통계2조치료총유효솔.결과 치료조유효28례,총유효솔위87.5%;대조조유효20례,총유효솔위62.5%,2조료효비교차이유통계학의의(x2=5.33,P＜0.05),치료조치료후HDS평분명현고우대조조[치료후15 d:(13.6±2.3)분비(9.4±2.1)분,P＜0.05;치료후30 d:(19.3±2.1)분비(12.8±2.7)분,P＜0.01].결론 의체랍봉、은행협제취물주사액연합고압양치료DEACMP료효호,치득림상추엄.
Objective To research the clinical curative effect of edaravone and extract of gingo biloba leaves injection combined hyperbaric oxygen for treatment of delayed encephalopathy after carbon monoxide poisoning (DEACMP). Methods Sixty-four patients with DEACMP were randomly divided into treatment group of 32 cases and control group of 32 cases. The basic treatments of two groups were identical. Based on the basic treatments, treatment group was treated with edaravone 30 mg/d, intravenously drip for 14 days, plug extract of gingo biloba leaves injection 70 mg/d, intravenously drip for 30 days. The changes of HDS were measured and the total effective rate were counted in two groups before and after treatment. Results The total effective rate in treatment group was 87.5% , and while control group was 62. 5%. The total effective rate had a significant difference in two groups (P＜0.05). The improvement of HDS in the treatment group was more significant than that in control group (P＜ 0. 05). Conclusion Edaravone and extract of gingo biloba leaves injection combined hyperbaric oxygen has favorable cognitive effect on DEACMP.
