CAJ | 학술논문

尾型同源盒转录因子2(CDX2)是一种特异性核转录因子,在肠上皮细胞正常发育分化和癌组织发生发展过程中起着关键作用,并且在肠上皮细胞形态的维持中起着重要作用.肝肠-钙黏连蛋白(CDH17)作为一种与肿瘤侵袭和转移密切相关的蛋白,在胃黏膜上皮同样高特异性表达.最近发现CDX2与CDH17与胃癌的发生、分化、转移等密切相关,二者有望成为胃癌诊断新的生物学标志和肿瘤基因治疗新靶点.
미형동원합전록인자2(CDX2)시일충특이성핵전록인자,재장상피세포정상발육분화화암조직발생발전과정중기착관건작용,병차재장상피세포형태적유지중기착중요작용.간장-개점련단백(CDH17)작위일충여종류침습화전이밀절상관적단백,재위점막상피동양고특이성표체.최근발현CDX2여CDH17여위암적발생、분화、전이등밀절상관,이자유망성위위암진단신적생물학표지화종류기인치료신파점.
Caudal-related homeobox transcription factor CDX2 is a specific nuclear transcription factor. It seems to play a key role in intestinal development and differentiation in normal and cancer tissues, and it is important for the maintenance of intestinal epithelium cells, liver-intestine cadherin(CDHIT) as one protein has intimate correlation with invasion and metastasis of tumor, has as well as highly expresses in intestinal-mucosa. Recent studies indicate that CDX2 and CDHI7 is closely associated with tumorigenesis,differentia-tion and metastasis. They might act as a new biomarker of gastric cancer diagnosis and a new target of tumor gene therapy.