CAJ | 학술논문

目的研究不同类型老年女性髋部骨折中外周、局部IGF-I及IGFBP-3,4,5表达差异及相关性.方法选取年龄大于65岁老年女性髋部骨折患者,比较外周及局部IGF-I及IGFBP-3,4,5表达差异及其相关性.结果共收集46例患者血清及局部指标,粗隆间骨折组粗隆区BMD较股骨颈骨折组低(P<0.001),股骨颈组血清及局部IGFBP-4含量较粗隆问骨折组低(P<0.001),而IGF-I及IGFBP-3,5含量高于粗隆广日J骨折组(P<0.001).局部蛋白同血清指标无相关性,相同指标间只有局部IGFBP-4 mRAN同血清相关指标成正相关(R=0.544,P<0.001).结论外周血清及局部中IGF-I及其结合蛋白表达的差异可能是导致不同类型老年髋部骨折的病理机制之一,但除IGFBP-4外,其他因子可能通过不同的调节机制影响老年髋部局部的骨代谢.
목적 연구불동류형노년녀성관부골절중외주、국부IGF-I급IGFBP-3,4,5표체차이급상관성.방법 선취년령대우65세노년녀성관부골절환자,비교외주급국부IGF-I급IGFBP-3,4,5표체차이급기상관성.결과 공수집46례환자혈청급국부지표,조륭간골절조조륭구BMD교고골경골절조저(P<0.001),고골경조혈청급국부IGFBP-4함량교조륭문골절조저(P<0.001),이IGF-I급IGFBP-3,5함량고우조륭엄일J골절조(P<0.001).국부단백동혈청지표무상관성,상동지표간지유국부IGFBP-4 mRAN동혈청상관지표성정상관(R=0.544,P<0.001).결론 외주혈청급국부중IGF-I급기결합단백표체적차이가능시도치불동류형노년관부골절적병리궤제지일,단제IGFBP-4외,기타인자가능통과불동적조절궤제영향노년관부국부적골대사.
Objective To study the expression difference of the insulin-like growth factor-I (IGF-I)and IGF-binding proteins-3,4,5(IGFBP-3,4,5)in the peripheral and local areas in senile hip fracture and discuss the correlation between the expression and the fracture types. Methods The study involved the senile patients (over 65 years) with hip fractures to compare the expressions of peripheral and local IGF-I and IGFBP-3,4,5 and observe the correlation between expression and fracture type.Results The serum and local specimens of 46 patients were collected,with lower level of BMD,IGF-I and IGFBP-3,5 in the intertrochanteric fracture group than the femoral neck fracture group(P<0.001)and with higher level of serum and local IGFBP-4 in the intertrochanteric fracture group than the femoral neck fracture group (P<0.001).Only local IGFBP-4 mRNA had positive correlation with serum markers (R=0.544,P<0.001). Conclusions The expression difference of IGF-I and IGFBP in the peripheral and local serum may be one of pathogenesis leading to different types of hip fractures.Except for the IGFBP-4,the other factors may affect the bone metabolism of the senile hip fractures through different regulatory mechanisms.