生殖与避孕(英文版)
生殖與避孕(英文版)
생식여피잉(영문판)
REPRODUCTION & CONTRACEPTION
2002年
2期
84-89
,共6页
韩丽晖%董源芬%王清%龚泉%谢琤%范慧民
韓麗暉%董源芬%王清%龔泉%謝琤%範慧民
한려휘%동원분%왕청%공천%사쟁%범혜민
endometrium%implant%endothelin
Objective To investigate endometrial endothelin type Ⅰ (ET-Ⅰ) level during menstru-al cycle and its change after implant insertionfrom 27 healthy women using radio-immunity technology. ET-Ⅰ level in proliferationperiod and secretion period were measured and compared. ET-Ⅰ level before and 3 to 7months after implant insertion were also compared. The side effect of long term use ofimplant was also study by measuring the ET-Ⅰ level among women 24 to 36 monthsafter implant insertion.Results ET-Ⅰ level in proliferation period was 2. 76± 1.25 pg/mg, which was sig-nificantly(P< 0. 05) lower than that in secretion period (3. 90±1.30 pg/mg). ET-Ⅰlevel in 14 women, from whom samples before and 3 to 7 months after implant insertionwere obtained, were3.38±1. 17 pg/mg and 10. 86± 3. 93 pg/mg respectively, withsignificant statistical difference (P< 0. 001). At different periods of implant inser-tion, the average ET-Ⅰ level was 10. 86± 3. 93 pg/mg within 2 to 3 years after im-plant insertion, significantly higher than that of women have implant insertion formore than 24 to 36 months year.Conclusion ET-Ⅰ level changes periodically. ET-Ⅰ level 3 to 7 months after implantinsertion was significantly higher than that before insertion, and drops as time goes.The increase of ET-Ⅰ level is possibly related to irregular uterine bleeding after the useof implant.