中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2005年
31期
226-228
,共3页
杨建庄%闫君宝%郑天珍%瞿颂义%李伟
楊建莊%閆君寶%鄭天珍%瞿頌義%李偉
양건장%염군보%정천진%구송의%리위
决明子/药理学%肥胖症%体重
決明子/藥理學%肥胖癥%體重
결명자/약이학%비반증%체중
背景:决明子具有降血压、降血脂、保肝及抑菌等活性,其减肥效应值得进一步探讨.目的:观察大鼠生理状态下自然饮用决明子水煎剂对营养性肥胖大鼠体质量的影响.设计:完全随机分组设计,对照实验,多组间比较采用方差分析和q检验.单位:河南科技大学第二附属医院心血管病研究室.材料:实验于2004-03/2004-09在河南科技大学第二附属医院心血管病研究室完成.选用雄性SD大鼠27只.将大鼠随机分为3组:正常对照组、模型对照组和决明子组,每组9只.方法:[1]正常对照组喂基础饲料(蛋白质、脂肪、碳水化合物含量分别是18.2%,4.5%,55.2%,每克含14.54 kJ热量),自然饮水;模型对照组喂高营养性饲料(蛋白质、脂肪、碳水化合物含量分别是23.7%,21.6%,39.0%,每克含19.56 kJ热量),自然饮水;决明子组喂高营养性饲料,自然饮不同浓度的决明子水煎剂.决明子水煎剂的浓度从10 g/L(相当于每毫升含决明子生药10 mg)开始,每天增加一个百分比浓度(即10 g/L)直到第6天增至60g/L,从第7天开始保持60g/L的浓度不变直至实验第7周结束.[2]每天定时记录进食量和饮水量,计算摄入热量(进食质量×每克所含热量),每周定时测体质量.第7周末,测量大鼠体长,计算Lee's指数3√体质量(g)×103/体长(cm)].[3]多组间比较采用方差分析和q检验.主要观察指标:决明子对营养性肥胖大鼠体质量、Lee,s指数、进食量、摄入热量和饮水量的影响.结果:大鼠27只均进入结果分析.[1]体质量:实验第3～7周模型对照组的明显高于正常对照组(P＜0.05～0.01).实验第2～7周决明子组明显低于模型对照组(P＜0.05～0.01).[2]Lee's指数:实验第7周模型对照组和决明子组大鼠明显大于正常对照组[(358.60±8.55),(341.84±7.29),(322.00±6.89)g/cm,P＜0.05～0.01],决明子组明显低于模型对照组(P＜0.05).[3]进食量:模型对照组和决明子组明显低于正常对照组(P＜0.05～0.01);决明子组与模型对照组相近(P＞0.05).[4]摄入热量:模型对照组和决明子组明显高于正常对照组(P＜0.05～0.01).决明子组与模型对照组相近(P＞0.05).[5]饮水量:决明子组基本与和模型对照组正常对照组相近(P＞0.05).模型对照组与正常对照组相近(P＞0.05).这表明60 g/L'质量浓度的决明子水煎剂不影响食欲.结论:质量浓度60g/L的决明子水煎剂既能明显抑制营养性肥胖大鼠体质量的增加,且不影响食欲.
揹景:決明子具有降血壓、降血脂、保肝及抑菌等活性,其減肥效應值得進一步探討.目的:觀察大鼠生理狀態下自然飲用決明子水煎劑對營養性肥胖大鼠體質量的影響.設計:完全隨機分組設計,對照實驗,多組間比較採用方差分析和q檢驗.單位:河南科技大學第二附屬醫院心血管病研究室.材料:實驗于2004-03/2004-09在河南科技大學第二附屬醫院心血管病研究室完成.選用雄性SD大鼠27隻.將大鼠隨機分為3組:正常對照組、模型對照組和決明子組,每組9隻.方法:[1]正常對照組餵基礎飼料(蛋白質、脂肪、碳水化閤物含量分彆是18.2%,4.5%,55.2%,每剋含14.54 kJ熱量),自然飲水;模型對照組餵高營養性飼料(蛋白質、脂肪、碳水化閤物含量分彆是23.7%,21.6%,39.0%,每剋含19.56 kJ熱量),自然飲水;決明子組餵高營養性飼料,自然飲不同濃度的決明子水煎劑.決明子水煎劑的濃度從10 g/L(相噹于每毫升含決明子生藥10 mg)開始,每天增加一箇百分比濃度(即10 g/L)直到第6天增至60g/L,從第7天開始保持60g/L的濃度不變直至實驗第7週結束.[2]每天定時記錄進食量和飲水量,計算攝入熱量(進食質量×每剋所含熱量),每週定時測體質量.第7週末,測量大鼠體長,計算Lee's指數3√體質量(g)×103/體長(cm)].[3]多組間比較採用方差分析和q檢驗.主要觀察指標:決明子對營養性肥胖大鼠體質量、Lee,s指數、進食量、攝入熱量和飲水量的影響.結果:大鼠27隻均進入結果分析.[1]體質量:實驗第3～7週模型對照組的明顯高于正常對照組(P＜0.05～0.01).實驗第2～7週決明子組明顯低于模型對照組(P＜0.05～0.01).[2]Lee's指數:實驗第7週模型對照組和決明子組大鼠明顯大于正常對照組[(358.60±8.55),(341.84±7.29),(322.00±6.89)g/cm,P＜0.05～0.01],決明子組明顯低于模型對照組(P＜0.05).[3]進食量:模型對照組和決明子組明顯低于正常對照組(P＜0.05～0.01);決明子組與模型對照組相近(P＞0.05).[4]攝入熱量:模型對照組和決明子組明顯高于正常對照組(P＜0.05～0.01).決明子組與模型對照組相近(P＞0.05).[5]飲水量:決明子組基本與和模型對照組正常對照組相近(P＞0.05).模型對照組與正常對照組相近(P＞0.05).這錶明60 g/L'質量濃度的決明子水煎劑不影響食欲.結論:質量濃度60g/L的決明子水煎劑既能明顯抑製營養性肥胖大鼠體質量的增加,且不影響食欲.
배경:결명자구유강혈압、강혈지、보간급억균등활성,기감비효응치득진일보탐토.목적:관찰대서생리상태하자연음용결명자수전제대영양성비반대서체질량적영향.설계:완전수궤분조설계,대조실험,다조간비교채용방차분석화q검험.단위:하남과기대학제이부속의원심혈관병연구실.재료:실험우2004-03/2004-09재하남과기대학제이부속의원심혈관병연구실완성.선용웅성SD대서27지.장대서수궤분위3조:정상대조조、모형대조조화결명자조,매조9지.방법:[1]정상대조조위기출사료(단백질、지방、탄수화합물함량분별시18.2%,4.5%,55.2%,매극함14.54 kJ열량),자연음수;모형대조조위고영양성사료(단백질、지방、탄수화합물함량분별시23.7%,21.6%,39.0%,매극함19.56 kJ열량),자연음수;결명자조위고영양성사료,자연음불동농도적결명자수전제.결명자수전제적농도종10 g/L(상당우매호승함결명자생약10 mg)개시,매천증가일개백분비농도(즉10 g/L)직도제6천증지60g/L,종제7천개시보지60g/L적농도불변직지실험제7주결속.[2]매천정시기록진식량화음수량,계산섭입열량(진식질량×매극소함열량),매주정시측체질량.제7주말,측량대서체장,계산Lee's지수3√체질량(g)×103/체장(cm)].[3]다조간비교채용방차분석화q검험.주요관찰지표:결명자대영양성비반대서체질량、Lee,s지수、진식량、섭입열량화음수량적영향.결과:대서27지균진입결과분석.[1]체질량:실험제3～7주모형대조조적명현고우정상대조조(P＜0.05～0.01).실험제2～7주결명자조명현저우모형대조조(P＜0.05～0.01).[2]Lee's지수:실험제7주모형대조조화결명자조대서명현대우정상대조조[(358.60±8.55),(341.84±7.29),(322.00±6.89)g/cm,P＜0.05～0.01],결명자조명현저우모형대조조(P＜0.05).[3]진식량:모형대조조화결명자조명현저우정상대조조(P＜0.05～0.01);결명자조여모형대조조상근(P＞0.05).[4]섭입열량:모형대조조화결명자조명현고우정상대조조(P＜0.05～0.01).결명자조여모형대조조상근(P＞0.05).[5]음수량:결명자조기본여화모형대조조정상대조조상근(P＞0.05).모형대조조여정상대조조상근(P＞0.05).저표명60 g/L'질량농도적결명자수전제불영향식욕.결론:질량농도60g/L적결명자수전제기능명현억제영양성비반대서체질량적증가,차불영향식욕.
BACKGROUND: Cassia seed acts on decreasing blood pressure and blood lipid, protecting liver and inhibiting bacteria. It is worth to carry on a further discussion on its effect of weight loss.OBJECTIVE: To observe the influence of cassia seed decoction drunk naturally on body mass of nutritional obese rats in physiological state.DESIGN: Completely randomized grouping was designed, in which, control experiment, analysis of variance and q test were applied in comparison among groups.SETTING: Cardiovascular Institute, Second Affiliated Hospital, Henan University of Science and Technology.MATERIALS: The experiment was performed in Cardiovascular Instutute,Second Affiliated Hospital, Henan University of Science and Technology from March 2004 to September 2004, in which, 27 male SD rats were employed and randomized into 3 groups, named normal control group, model group and cassia seed group, 9 rats in each one.METHODS: [1] In normal control, the rats were bred with basic forage(the contents of protein, fat, carbohydrate were 18.2%, 4.5% and 55.2%successively, with 14.54 kJ caloric each gram) and drank water naturally.In model group, the rats were bred with high nutritive forage (the contents of protein, fat, carbohydrate were 23.7%, 21.6% and 39.0% successively,with 19.56 kJ caloric each gram) and drank water naturally. In cassia seed group, the rats were bred with high nutritive forage and drank cassia seed decoction of various concentration naturally. The concentration of cassia seed decoction started at 10 g/L (equally contained 10 mg raw cassia seed each milliliter) and was increased by 100% concentration each day (10 g/L)till to 60 g/L on the 6th day. Since the 7th day, the concentration of 60 g/L was maintained till to the 7th weekend. [2] It was to record appetite and drinking quantity at definite time every day and calculate absorbed caloric(intake mass × caloric contained each gram). It was to measure body mass at definite time each week. On the 7th weekend, the body length of rat was measured and Lee's index was calculated [ 3√body mass (g)×103/body length (cm)]MAIN OUTCOME MEASURES: Influences of cassia seed on body mass, Lee's index, appetite, caloric and drinking quantity in nutritional obese rats.RESULTS: Twenty-seven rats all entered result analysis. [1] Body mass:that in model group from the 3rd to 7th week in experiment group was higher remarkably than normal control group (P ＜ 0.05-0.01). That in cassia seed group from the 2nd to 7th week was lower remarkably than that in the model group (P ＜ 0.05-0.01). [2] Lee's index: that in model group and cassia seed group on the 7th week of experiment was higher remarkably than that in the normal control group [(358.60±8.55), (341.84±7.29), (322.00±6.89) g/cm, P ＜ 0.05-0.01] and that in cassia seed group was lower remarkably than that in the model group (P ＜ 0.05). [3] Appetite: that in model group and cassia seed group was lower remarkably than that in the normal control group (P ＜ 0.05-0.01) and that in cassia seed group was near to the control group (P ＞ 0.05). [4] Absorbed caloric: that in model group and cassia seed group was higher remarkably than that in the normal control group (P ＜ 0.05-0.01) and that in cassia seed group was near to the control group (P ＞ 0.05). [5] Drinking quantity: that in cassia seed group was basically near to that in the model group and the control group (P ＞ 0.05) and that in model group was near to the control group. It was indicated that cassia seed decoction at mass concentration of 60 g/L did not affect appetite.CONCLUSION: Cassia seed decoction at mass concentration of 60 g/L inhibits remarkably the increased body mass of nutritional obese rats and is free from influence on appetite.
