CAJ | 학술논문

目的观察向心性肥胖患者的8-异前列腺素(8-iso-PGF2a)水平及其与胰岛素抵抗的关系.方法筛选糖耐量正常的向心性肥胖患者(包括胰岛素抵抗与无胰岛素抵抗者)及正常对照组.分别测定血清8-iso-PGF2a,丙二醛(MDA),游离脂肪酸(FFA)等.结果向心性肥胖组8-iso-PGF2a、MDA、胰岛素抵抗指数(HOMA-IR)、FFA均显著高于对照组(P＜0.05).8-iso-PGF2a差异最显著(P＜0.01),且与FFA、BMI及甘油三酯(TG)呈显著正相关.胰岛素抵抗亚组的8-iso-PGF2a水平显著高于无胰岛素抵抗亚组.多元回归分析显示,8-iso-PGF2a与HOMA-IR相关性最强.结论糖耐量正常的向心性肥胖患者氧化应激增强,且氧化应激是胰岛素抵抗的重要危险因素,循环中子8-iso-PGF2a水平能更好地反映其程度.
목적 관찰향심성비반환자적8-이전렬선소(8-iso-PGF2a)수평급기여이도소저항적관계.방법 사선당내량정상적향심성비반환자(포괄이도소저항여무이도소저항자)급정상대조조.분별측정혈청8-iso-PGF2a,병이철(MDA),유리지방산(FFA)등.결과 향심성비반조8-iso-PGF2a、MDA、이도소저항지수(HOMA-IR)、FFA균현저고우대조조(P＜0.05).8-iso-PGF2a차이최현저(P＜0.01),차여FFA、BMI급감유삼지(TG)정현저정상관.이도소저항아조적8-iso-PGF2a수평현저고우무이도소저항아조.다원회귀분석현시,8-iso-PGF2a여HOMA-IR상관성최강.결론 당내량정상적향심성비반환자양화응격증강,차양화응격시이도소저항적중요위험인소,순배중자8-iso-PGF2a수평능경호지반영기정도.
Objective To investigate the level of 8-iso-prostaglandin F2α（8-iso-PGF2α）and its relationship with insulin resistance in central obese patients with NGT. Methods Two hundred and twenty-two subjects were enrolled and divided into two groups: central obese group (n=123) and normal control group(NC, n=99). The central obese group was subdivided into insulin resistance(IR) group and non-IR group. Serum 8-iso-PGF2α, malondialdehyde (MDA), free fatty acids (FFA), IL-6, TNF-α， and lipid were measured. Results Compared with the control group, the levels of 8-iso-PGF2α(P= 0.001), body mass index(BMI), waist circumference(WC), triglyceride (TG), cholesterol (TC), high density lipoprotein(HDL), FFA, MDA and insulin resistance index (HOMA-IR) significantly increased in obese group(all P<0.05), and they increased even more in IR sub-group than those in non-IR sub-group.The level of 8-iso-PGF2α had independently positive correlation with HOMA-IR. Conclusion Oxidative stress increases in central obese patients with NGT,and it plays an important role in insulin resistance. The level of serum 8-iso-PGF2α is a better parameter indicating the extent of oxidative stress.