CAJ | 학술논문

半胱氨酸天冬氨酸特异性蛋白酶( caspases)是一类同源蛋白酶,主要参与细胞的凋亡过程.近年来的研究表明,该家族部分成员在T细胞活化与增殖中亦发挥重要作用,主要体现在以下3个方面:T细胞活化过程中检测到多种caspases活性；caspase-8失活后导致了人与鼠T细胞免疫的缺陷；体外实验中,caspase抑制剂能够阻断抗CD3单抗及超抗原引起的T细胞的活化与增殖.目前,部分体内实验已经证实了caspase抑制剂抗免疫反应及抗炎症反应的有效性,这为免疫性及炎症性疾病提供了新的治疗思路,为研制新型抗免疫、抗炎药物提供了依据.
반광안산천동안산특이성단백매( caspases)시일류동원단백매,주요삼여세포적조망과정.근년래적연구표명,해가족부분성원재T세포활화여증식중역발휘중요작용,주요체현재이하3개방면:T세포활화과정중검측도다충caspases활성；caspase-8실활후도치료인여서T세포면역적결함；체외실험중,caspase억제제능구조단항CD3단항급초항원인기적T세포적활화여증식.목전,부분체내실험이경증실료caspase억제제항면역반응급항염증반응적유효성,저위면역성급염증성질병제공료신적치료사로,위연제신형항면역、항염약물제공료의거.
Caspases (Cysteine-dependent aspartate-specific proteases) are a family of cysteine proteases that play important roles in regulating apoptosis.Recent studies have shown that some caspases related to apoptosis also participate in the activation and proliferation of T lymphocytes.This can be reflected in three aspects:several caspases were detected in the activation and proliferation of T lymphocytes; inactivation of caspase-8 in vivo resulted in T cell immune deficiency in both human and mouse; in vitro proliferation and activation of T lymphocytes,induced by anti-CD3 monoclonal antibody or superantigen could induce were blocked when caspase inhibitor was added at the same time.In vivo investigations have confirmed the anti-immune and anti-inflammatory effects of caspase inhibitor,These studies provided new approach for the treatment of immune and inflammatory for the development of new anti-immune and anti-inflammatory drugs.