CAJ | 학술논문

目的系统评价近视欠矫和足矫对6～16岁学龄儿童近视进展的影响.方法 Meta分析.通过计算机检索Medline(1966～2010.10)、EMBASE(1950～2010.10),Coehrane Library、Clinicaltrials.gov、中国生物医学文献数据库(1980～2010.10)和中国l临床试验注册中心以及相关会议文献,对所检索到的随机对照试验文献进行双人独立筛选,采用Jadad量表评估纳入文献的质量,提取数据并用Review Manager 5.0软件进行Meta分析,采用失安全系数评估发表偏倚.结果纳入5篇文献,共计428例受试者,其中足矫组215例.Meta分析结果显示欠矫组与足矫组屈光度进展量差异的加权平均差为-0.26 D(95%CI:-0.60～0.09,P=0.14).去除Jadad评分3分以下的3篇文章,并采用固定效应模型进行敏感性分析,两组屈光度进展量差异的加权平均差为-0.21 D(95%CI:-0.32～-0.10,P=0.0002),失安全系数为8.结论与近视欠矫患儿相比,足矫可能可以轻度延缓学龄儿童近视进展,但仍需更多高质量的随机对照试验进一步验证.
목적 계통평개근시흠교화족교대6～16세학령인동근시진전적영향.방법 Meta분석.통과계산궤검색Medline(1966～2010.10)、EMBASE(1950～2010.10),Coehrane Library、Clinicaltrials.gov、중국생물의학문헌수거고(1980～2010.10)화중국l림상시험주책중심이급상관회의문헌,대소검색도적수궤대조시험문헌진행쌍인독립사선,채용Jadad량표평고납입문헌적질량,제취수거병용Review Manager 5.0연건진행Meta분석,채용실안전계수평고발표편의.결과 납입5편문헌,공계428례수시자,기중족교조215례.Meta분석결과현시흠교조여족교조굴광도진전량차이적가권평균차위-0.26 D(95%CI:-0.60～0.09,P=0.14).거제Jadad평분3분이하적3편문장,병채용고정효응모형진행민감성분석,량조굴광도진전량차이적가권평균차위-0.21 D(95%CI:-0.32～-0.10,P=0.0002),실안전계수위8.결론 여근시흠교환인상비,족교가능가이경도연완학령인동근시진전,단잉수경다고질량적수궤대조시험진일보험증.
Objective To systematically evaluate the effects of under correction and full correction of myopia in slowing the progression of myopia in schoolchildren aged 6 to 16 years. Methods Meta-analysis. We searched MEDLINE (1966-2010.10), EMBASE (1950-2010.10), the Cochrane Library, Clinicaltrials.gov, CBM (1980-2010.10) and the Chinese Clinical Trial Registry, and related conference proceedings. The articles retrieved were independently screened by two reviewers. The quality of the selected trials was assessed using a Jadad scale. Review Manager 5.0 software was used to perform the meta-analysis of the extracted data. And the fail-safe N was calculated to assess the potential for publication bias. Results Five trials were included with a total of 428 subjects, of whom 215 subjects had a full correction of their myopia. The results of the meta-analysis showed that the weighted mean difference in the change of myopia progression between the under correction group and the full correction group was-0.26 D (95%CI:-0.60-0.09, P=0.14). After excluding the three trials with a Jadad score of less than 3, a fixed-effects sensibility analysis was conducted and the results showed that the weighted mean difference in the change of myopia progression between the two groups was-0.21 D (95%CI:-0.32--0.10, P=0.0002). The number of fail-safe N was 8. Conclusion Full correction of myopia may slightly slow the progression of myopia in school-aged children compared to under correction of myopia, which needs to be further verified by high-quality randomized controlled trials.