中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
7期
676-678
,共3页
朱瑾英%张慧娟%姜晓艳%周晖%华文芳%刘志杰%郝菲%俞秋霞
硃瑾英%張慧娟%薑曉豔%週暉%華文芳%劉誌傑%郝菲%俞鞦霞
주근영%장혜연%강효염%주휘%화문방%류지걸%학비%유추하
硝基酪氨酸%2型糖尿病%冠心病
硝基酪氨痠%2型糖尿病%冠心病
초기락안산%2형당뇨병%관심병
Nitrotyrosine%Type 2 diabetes mellitus%Coronary heart disease
目的 观察血清硝基酪氨酸水平与2型糖尿病(T2DM)冠心病(CHD)的关系.方法 应用ELISA免疫试剂盒测定109例糖尿病非冠心病患者(T2DM组)、152例糖尿病合并冠心病患者(T2DM-CHD组)和103名正常对照者(对照组)硝基酪氨酸浓度.结果 (1)T2DM-CHD组血清硝基酪氨酸浓度为(78.17±10.68)nmol/L,高于T2DM组[(70.50±9.13)nmol/L]及对照组[(63.23±11.55)nmol/L],差异均有统计学意义(P均＜0.01).(2)对所有糖尿病患者进行相关分析发现,硝基酪氨酸与总胆固醇、甘油三酯、空腹血糖、Gensini积分相关(r=0.361,P=0.009；r =0.206,P=0.001;r =0.347,P=0.026；r=0.466,P＜0.001).Logistic回归分析发现硝基酪氨酸是2型糖尿病合并冠心病的危险因素之一(OR=1.094,95％ CI:1.053 ～1.137;P ＜0.01).结论 硝基酪氨酸在2型糖尿病及2型糖尿病合并冠心病的发生过程中起重要作用.
目的 觀察血清硝基酪氨痠水平與2型糖尿病(T2DM)冠心病(CHD)的關繫.方法 應用ELISA免疫試劑盒測定109例糖尿病非冠心病患者(T2DM組)、152例糖尿病閤併冠心病患者(T2DM-CHD組)和103名正常對照者(對照組)硝基酪氨痠濃度.結果 (1)T2DM-CHD組血清硝基酪氨痠濃度為(78.17±10.68)nmol/L,高于T2DM組[(70.50±9.13)nmol/L]及對照組[(63.23±11.55)nmol/L],差異均有統計學意義(P均＜0.01).(2)對所有糖尿病患者進行相關分析髮現,硝基酪氨痠與總膽固醇、甘油三酯、空腹血糖、Gensini積分相關(r=0.361,P=0.009；r =0.206,P=0.001;r =0.347,P=0.026；r=0.466,P＜0.001).Logistic迴歸分析髮現硝基酪氨痠是2型糖尿病閤併冠心病的危險因素之一(OR=1.094,95％ CI:1.053 ～1.137;P ＜0.01).結論 硝基酪氨痠在2型糖尿病及2型糖尿病閤併冠心病的髮生過程中起重要作用.
목적 관찰혈청초기락안산수평여2형당뇨병(T2DM)관심병(CHD)적관계.방법 응용ELISA면역시제합측정109례당뇨병비관심병환자(T2DM조)、152례당뇨병합병관심병환자(T2DM-CHD조)화103명정상대조자(대조조)초기락안산농도.결과 (1)T2DM-CHD조혈청초기락안산농도위(78.17±10.68)nmol/L,고우T2DM조[(70.50±9.13)nmol/L]급대조조[(63.23±11.55)nmol/L],차이균유통계학의의(P균＜0.01).(2)대소유당뇨병환자진행상관분석발현,초기락안산여총담고순、감유삼지、공복혈당、Gensini적분상관(r=0.361,P=0.009；r =0.206,P=0.001;r =0.347,P=0.026；r=0.466,P＜0.001).Logistic회귀분석발현초기락안산시2형당뇨병합병관심병적위험인소지일(OR=1.094,95％ CI:1.053 ～1.137;P ＜0.01).결론 초기락안산재2형당뇨병급2형당뇨병합병관심병적발생과정중기중요작용.
Objective To investigate the association of nitrotyrosine with coronary heart disease (CHD) in type 2 diabetes mellitus.Methods The nitrotyrosine levels were determined in 109 patients of type 2 diabetes mellitus without CHD (T2DM).One hundred and fifty-two patients of type 2 diabetes mellitus with CHD (T2DM-CHD) and 103 healthy control subjects by ELISA.Results T2DM-CHD patients had significantly increased nitrotyrosine compared with T2DM group and the control group [ ( 78.17±10.68 )nmol/L,(70.50 ± 9.13) nmol/L vs ( 63.23 ± 11.55 ) nmol/L,Ps ＜ 0.01 ].Nitrotyrosine was correlated with total cholesterol,triglyceride,fasting glucose and Gensini Score (r=0.361,P=0.009;r =0.206,P=0.001 ;r=0.347,P=0.026; r=0.466,P ＜ 0.001 ).Multivariable logistic regression showed nitrotyrosine was independently associated with CHD combined with type 2 diabetes mellitus ( OR=1.094,95％ CI:1.053-1.137 ; P ＜ 0.01 ).Conclusion Nitrotyrosine plays an important role in the formation and development of cardiovascular disease in tvoe 2 diabetes.
