CAJ | 학술논문

目的探讨阿片受体激动剂布托啡诺对正常及内毒素休克时肺动脉血管反应性的影响,从而指导临床用药.方法应用血管环张力检测技术,观察布托啡诺对正常及脂多糖(lipopolysaccharide,LPS 4 μg/ml,4 h)孵育的肺动脉血管环反应性的影响.结果在正常肺动脉组,布托啡诺终浓度(0.1 μmol/L,1 μmol/L,10μmol/L,100 μmol/L)使苯肾上腺素(Phenylephrine,PE)预收缩的肺动脉呈剂量依赖性舒张,在LPS孵育的肺动脉组,布托啡诺终浓度(0.1 μmol/L,1μmol/L,10μmol/L,100 μmol/L)也使PE预收缩的肺动脉呈剂量依赖性舒张反应,但其舒张作用与正常组比较明显加强.结论布托啡诺对血管具有直接的舒张反应,并且LPS可以增强布托啡诺对肺动脉的最大舒张反应.
목적 탐토아편수체격동제포탁배낙대정상급내독소휴극시폐동맥혈관반응성적영향,종이지도림상용약.방법 응용혈관배장력검측기술,관찰포탁배낙대정상급지다당(lipopolysaccharide,LPS 4 μg/ml,4 h)부육적폐동맥혈관배반응성적영향.결과 재정상폐동맥조,포탁배낙종농도(0.1 μmol/L,1 μmol/L,10μmol/L,100 μmol/L)사분신상선소(Phenylephrine,PE)예수축적폐동맥정제량의뢰성서장,재LPS부육적폐동맥조,포탁배낙종농도(0.1 μmol/L,1μmol/L,10μmol/L,100 μmol/L)야사PE예수축적폐동맥정제량의뢰성서장반응,단기서장작용여정상조비교명현가강.결론 포탁배낙대혈관구유직접적서장반응,병차LPS가이증강포탁배낙대폐동맥적최대서장반응.
Objective To explore the regulatory roles of butorphanol on isolated rabbit pulmonary arteries by lipopolysaccharide(LPS)pre-incubation and assay the protective effect of ketamine on clinic sep tic shock patients.Methods Vascular ring tension detection technique was applied to observe the effect of butorphanol on the normal or lipopolysaccharide incubated pulmonaryvascular.Results In normal group, the final concentration of butorphanol(0.1 μmol,1μmol,10μmol,100μmol)were used to make pretreat ment- phenylephrine(PE)pulmonary artery relaxation.In LPS group,the effect of vasodilation of butor phanol was enhanced.Conclusions LPS can enhance the effect of butorphanol on pulmonary artery relaxa tion reaction.And the direct effect of butorphanol on pulmonary arteries was vasodilation.