CAJ | 학술논문

11β-羟类固醇脱氧酶1型(11β-HSD1)是一种糖皮质激素(GC)的调节酶,参与中枢神经系统组织局部GC水平与活性的调节.其能使无活性的酮还原成有活性的GC,从而放大中枢GC的作用,致使局部GC水平过高,进而直接损伤海马,影响认知功能.11β-HSD1抑制剂和过氧化物酶体增殖物活化受体(PPAR)-γ激动剂,通过抑制和下调11β-HSD1的表达,能够改善伴有认知功能障碍的疾病如阿尔茨海默病(AD)、遗忘型轻度认知障碍患者的认知水平.
11β-간류고순탈양매1형(11β-HSD1)시일충당피질격소(GC)적조절매,삼여중추신경계통조직국부GC수평여활성적조절.기능사무활성적동환원성유활성적GC,종이방대중추GC적작용,치사국부GC수평과고,진이직접손상해마,영향인지공능.11β-HSD1억제제화과양화물매체증식물활화수체(PPAR)-γ격동제,통과억제화하조11β-HSD1적표체,능구개선반유인지공능장애적질병여아이자해묵병(AD)、유망형경도인지장애환자적인지수평.
11β p-hydroxysteroid dehydrogenase type 1( 11β-HSD1 ) , a glucocorticoid ( GC ) regulatory enzyme,is involved in the regulation of GC from level to activity in the central nervous system. 11β-HSD1 mediates the conversion of cortisone to cortisol, amyplifying the action of local GC. The higher level of intra-cellular GC in brain results in the lesion of the hippocampus and the impairment of cognition. Inhibition of 11β-HSD1 or peroxisome proliferator-activated receptor ( PPAR) -γ agonists can improve the cognitive dysfunction associated with diseases such as Alzheimer disease (AD) and amnestic mild cognitive impairment, by inhibiting or reducing the expression of 11β-HSD1.