CAJ | 학술논문

肠道病毒71(EV71)是引起手足口病(HFMD)的主要病原体之一,同时也是肠道病毒属中能引起无菌性脑膜炎、脑炎和脊髓灰质炎样麻痹等多种神经系统相关疾病的一种病原体.20世纪90年代后期以来,EV71在亚太地区多次流行,期间有很多关于该病毒引起的婴幼儿神经源性肺水肿病例及死亡病例的报道,引起了人们的高度重视.因此,阐明EV71的致病机制对于该病的预防和治疗至关重要.此文对病毒结构蛋白、非结构蛋白、病毒结合蛋白、受体及信号调节因子等方面与致病机制的关系进行分析,以期对EV71的致病机制有更深刻地理解,从而为有效的疫苗和药物研制提供新的思路.
장도병독71(EV71)시인기수족구병(HFMD)적주요병원체지일,동시야시장도병독속중능인기무균성뇌막염、뇌염화척수회질염양마비등다충신경계통상관질병적일충병원체.20세기90년대후기이래,EV71재아태지구다차류행,기간유흔다관우해병독인기적영유인신경원성폐수종병례급사망병례적보도,인기료인문적고도중시.인차,천명EV71적치병궤제대우해병적예방화치료지관중요.차문대병독결구단백、비결구단백、병독결합단백、수체급신호조절인자등방면여치병궤제적관계진행분석,이기대EV71적치병궤제유경심각지리해,종이위유효적역묘화약물연제제공신적사로.
Enterovirus 71 (EV71) is one of the major pathogenesis to cause hand, foot and mouth disease (HFMD) . EV71 is also one of the pathogeneses in enteroviruses, which can cause nervous system related disease such as aseptic meningitis, encephalitis and poliomyelitis-like paralysis. Since the late 1990s, there has been many epidemic activities throughout the Asia-Pacific region caused by EV71 and many reports about the infant neurotoxicity infections and deaths cases, and it has been paid great attention. Therefore, it is very important for the prevention and treatment of this disease to expound the pathogenesis of the diseases caused by EV71. This article focuses on the relations between virus structural proteins, non-structural proteins, virus binding proteins, receptors and signal regulating factors. It is helpful for further understanding about the pathogenesis and providing a new thinking to prepare the effective vaccines and drugs.