CAJ | 학술논문

应用时间分辨免疫荧光分析法对7698例妊娠15～20 +6周的妇女进行甲胎蛋白(AFP)和人绒毛膜促性腺激素游离β亚基(free-β-HCG)检测,筛出染色体异常高风险孕妇483例,其中344例接受羊水或脐血管穿刺产前诊断,发现胎儿染色体异常18例,异常检出率5.2%.筛出神经管缺陷高风险孕妇25例,经B超证实胎儿畸形6例,死胎2例,异常检出率32.O%.筛查高风险组和低风险组的妊娠不良结局分别为25.6%和7.7%,差异有统计学意义(P＜0.05).提示孕中期母血清筛查是预测胎儿染色体异常和神经管缺陷的有效指标,筛查高风险与母婴不良妊娠结局有相关性.
응용시간분변면역형광분석법대7698례임신15～20 +6주적부녀진행갑태단백(AFP)화인융모막촉성선격소유리β아기(free-β-HCG)검측,사출염색체이상고풍험잉부483례,기중344례접수양수혹제혈관천자산전진단,발현태인염색체이상18례,이상검출솔5.2%.사출신경관결함고풍험잉부25례,경B초증실태인기형6례,사태2례,이상검출솔32.O%.사사고풍험조화저풍험조적임신불량결국분별위25.6%화7.7%,차이유통계학의의(P＜0.05).제시잉중기모혈청사사시예측태인염색체이상화신경관결함적유효지표,사사고풍험여모영불량임신결국유상관성.
This study was to explore the value of maternal serum screen in identification of fetal abnormal chromosome and neural tube defect(NTD). By using time-distinguished fluorescence immunoassay, serum levels of free-β-HCG and alpha fetal protein(AFP)were obtained in 7698 pregnant women at 15～20 +6weeks. and 483 were found at a higher risk of fetal abnormal chromosome. Based on amniotic fluid examination or cord blood testing on 344 high. Risk participants. Fetal abnormal chromosome was found in 18 women with a positive rate of 5. 2%. Twenty-five pregnant women were NTD high-risk, and their positive rate was 0. 3%. B-mode ultrasound identified 6 fetal malformations and 2 fetal deaths ( positive rate of 32. 0%). In high-risk or low-risk group, there were 25. 6%and 7. 7%subjects developed adverse outcome, respectively(P＜0. 05). Our findings suggested that maternal serum screen is an effective prediction factor for fetal abnormal chromosome and NTD.