CAJ | 학술논문

目的探讨慢性乙型肝炎(CHB)患者血清维生素E水平与肝组织病理的关系.方法选择66例慢性乙型肝炎患者进行肝穿刺病理学检查,健康对照组10例.化学比色法检测血清维生素E表达水平,同时检测HBV DNA、HBeAg及肝功能.结果与正常对照组相比,慢性乙型肝炎患者血清维生素E水平明显降低(P<0.01);HBeAg阳性组与HBeAg阴性组比较,血清维生素E水平无明显差别(P0.05).CHB患者血清维牛素E水平与肝脏组织炎症呈负相关关系(r=-0.451,P<0.05),而与肝脏组织纤维化程度无明显相关(r=0.02,P0.05).结论维生素E作为体内重要的抗氧化剂,参与了慢性乙型肝炎的炎症过程.在肝脏炎症过程中,适当补充维生素E,可能有助于缓解病情.
목적 탐토만성을형간염(CHB)환자혈청유생소E수평여간조직병리적관계.방법 선택66례만성을형간염환자진행간천자병이학검사,건강대조조10례.화학비색법검측혈청유생소E표체수평,동시검측HBV DNA、HBeAg급간공능.결과 여정상대조조상비,만성을형간염환자혈청유생소E수평명현강저(P<0.01);HBeAg양성조여HBeAg음성조비교,혈청유생소E수평무명현차별(P0.05).CHB환자혈청유우소E수평여간장조직염증정부상관관계(r=-0.451,P<0.05),이여간장조직섬유화정도무명현상관(r=0.02,P0.05).결론 유생소E작위체내중요적항양화제,삼여료만성을형간염적염증과정.재간장염증과정중,괄당보충유생소E,가능유조우완해병정.
Objective To study on the relationship of serum vitamin E and liver pathological features in the patients with chronic hepatitis B. Methods Sixty-six patients with chronic hepatitis B and ten healthy controls were enrolled in this present study. The serum vitamin E level was measured spectrophotometrically. Comparisons of liver function test, HBeAg and HBV DNA level were conducted among different liver pathological features including inflammatory grading and fibrosis staging. Results Compared with healthy controls, the serum level of vitamin E was significantly decreased in the patients with chronic hepatitis B, especially in those with elevated ALT activity. In comparison between HBeAg positive group and HBeAg negative group, the serum level of vitamin E of the former group did not significantly changed (P 0.05). Furthermore, the serum level of vitamin E has been demonstrated to be negatively associated with the inflammation grading in the patients with chronic hepatitis B. However, there was no significant association between the serum vitamin E and liver fibrosis staging. Conclusion Vitamin E, as one of the important anti-oxidants, was demonstrated to be implicated in the progression of liver inflammation in the patients with chronic hepatitis B. Furthermore, the supplement of vitamin E would be a potential therapy for attenuate the inflammatory response.