中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2010年
12期
1788-1789,后插一-后插二
,共3页
前列腺癌%良性前列腺增生%EphA2
前列腺癌%良性前列腺增生%EphA2
전렬선암%량성전렬선증생%EphA2
Prostate cancer%Benign prostatic hyperplasia%Erythropoitin-producing hepatocellular A2
目的 探讨EphA2蛋白在前列腺癌中的表达及意义.方法 应用免疫组织化学方法检测EphA2蛋白在43例前列腺癌及20例良性前列腺增生组织中的表达.结果 EphA2在前列腺癌的免疫反应阳性为36例,阳性表达率为83.72%,显著高于良性前列腺增生组织(只有2例表达,P<0.05).EphA2表达与前列腺癌的临床分期、病理分级、血清前列腺特异性抗原(PSA)水平以及淋巴结转移密切相关(P<0.05),而与肿瘤大小及患者的发病年龄无明显相关.结论 过表达的EphA2蛋白与前列腺癌的发生、肿瘤细胞的侵袭和转移能力相关.
目的 探討EphA2蛋白在前列腺癌中的錶達及意義.方法 應用免疫組織化學方法檢測EphA2蛋白在43例前列腺癌及20例良性前列腺增生組織中的錶達.結果 EphA2在前列腺癌的免疫反應暘性為36例,暘性錶達率為83.72%,顯著高于良性前列腺增生組織(隻有2例錶達,P<0.05).EphA2錶達與前列腺癌的臨床分期、病理分級、血清前列腺特異性抗原(PSA)水平以及淋巴結轉移密切相關(P<0.05),而與腫瘤大小及患者的髮病年齡無明顯相關.結論 過錶達的EphA2蛋白與前列腺癌的髮生、腫瘤細胞的侵襲和轉移能力相關.
목적 탐토EphA2단백재전렬선암중적표체급의의.방법 응용면역조직화학방법검측EphA2단백재43례전렬선암급20례량성전렬선증생조직중적표체.결과 EphA2재전렬선암적면역반응양성위36례,양성표체솔위83.72%,현저고우량성전렬선증생조직(지유2례표체,P<0.05).EphA2표체여전렬선암적림상분기、병리분급、혈청전렬선특이성항원(PSA)수평이급림파결전이밀절상관(P<0.05),이여종류대소급환자적발병년령무명현상관.결론 과표체적EphA2단백여전렬선암적발생、종류세포적침습화전이능력상관.
Objective To investigate the expression and clinical significance of erythropoitin-producing hepatocellular (Eph) A2 protein in prostate cancer.Methods Immunohistochemistry was used to examine Eph2 expression in tissue samples from 43 patients with prostate cancers and 21 patients with benign prostatic hyperplasia.Results Thirty-six cases of prostate cancer were positive for EphA2 immunoreactivity with the positive rate being 83.72%,which was significantly higher than in benign prostatic hyperplasia ( P<0.05 ).The expression of EphA2 protein was correlated with the clinical stage,grade,level of prostate specific antigen (PSA) and lymph node metastasis (P<0.05 ),but not to the tumor size and the age of patients.Conclusion The overexpression of EphA2 protein had impact on tumorigenesis,migration and invasion of prostatic adenocarcinoma.
