CAJ | 학술논문

目的探讨肠内营养(EN)和肠内免疫微生态营养(EIN)对肝切除术后患者肝脏功能的影响.方法将82例肝切除患者随机分为两组,手术后分别接受肠内营养和肠内免疫微生态营养1周,观察两种营养方式对患者内毒素、细胞因子及肝功能的影响.结果术前EIN组内毒素、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及肝功能与EN组比较差异无统计学意义(P>0.05).营养支持1周后,EIN组内毒素、TNF-α和IL-6分别为(1.88±0.17)pg/ml、(260±28)pg/ml、(158±8)pg/ml,上述指标均较EN组明显下降(P<0.01或P<0.05).EIN组1周后肝功能各项指标与EN组比较差异有统计学意义(P<0.01或P<0.05).结论肠内免疫微生态营养,可以补充肠道正常菌群,减少细菌易位,减少内毒素血症及炎症因子的发生,从而减轻肝切除术后的肝损害.
목적 탐토장내영양(EN)화장내면역미생태영양(EIN)대간절제술후환자간장공능적영향.방법 장82례간절제환자수궤분위량조,수술후분별접수장내영양화장내면역미생태영양1주,관찰량충영양방식대환자내독소、세포인자급간공능적영향.결과 술전EIN조내독소、종류배사인자-α(TNF-α)、백세포개소-6(IL-6)급간공능여EN조비교차이무통계학의의(P>0.05).영양지지1주후,EIN조내독소、TNF-α화IL-6분별위(1.88±0.17)pg/ml、(260±28)pg/ml、(158±8)pg/ml,상술지표균교EN조명현하강(P<0.01혹P<0.05).EIN조1주후간공능각항지표여EN조비교차이유통계학의의(P<0.01혹P<0.05).결론 장내면역미생태영양,가이보충장도정상균군,감소세균역위,감소내독소혈증급염증인자적발생,종이감경간절제술후적간손해.
Objective To explore the effects of enteral nutrition(EN) and ecoimmunonutrition(EIN) support routes on liver function after hepatectomy. Methods In this study,82 patients were randomized into two groups to respectively receive enteral nutrition or ecoimmunonutrition support beginning the first day post-operation for a week. The level of plasma endotoxin, cytokines and hepatic function were recorded. Results The serum level of plasma endotoxin, TNF-α and IL-6 in EIN group were no difference comparied with EN group at preoperative phase. Seven days after nutrition support, the serum level of plasma endotoxin, TNF-α and IL-6 in EIN group were (1.88±0.17)pg/ml, (260±28)pg/ml,(158±8)pg/ml, respectively,which were all significantly lower than those of EN group (P<0.01 or P<0.05). The hepatic function in EIN group were significantly different in statistics than the EN group after one week(P<0.01 or P<0.05). Conclusions EIN can compensate for normal flora in the gut, reduce bacterial translocation, modulate immunologic function, attenuate the serum level of plasma endotoxin and cytokines, alleviate hepatic injury after hepatectomy.