国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2009年
1期
8-10
,共3页
张凤兰%高磊%王富华%代秀玉%谭丽霞%Alvin K H Kwo
張鳳蘭%高磊%王富華%代秀玉%譚麗霞%Alvin K H Kwo
장봉란%고뢰%왕부화%대수옥%담려하%Alvin K H Kwo
人工泪液%角膜厚度%Orbscan II角膜地形图系统
人工淚液%角膜厚度%Orbscan II角膜地形圖繫統
인공루액%각막후도%Orbscan II각막지형도계통
artificial tears%corneal thickness%Orbscan Corneal Topography System II
目的:研究人工泪液爱丽和倍然对成年近视眼角膜厚度的影响.方法:应用Orbscan II角膜地形图系统(Orbscan,Inc,Salt Lake City,UT,USA,Version 3.00E)对滴人工泪液爱丽或倍然0.5h后的最薄角膜厚度(THN)变化进行测量,38例(76眼)被随机分成爱丽组和倍然组,分别于滴药前和滴药后0.5h进行3次THN测量.结果:两组THN在滴药前无差异(t=0.264),但滴药0.5h后两组THN均显著增加(爱丽组5.57±7.00μm,t=4.906,P<0.01,倍然组7.89±7.64μm,t=6.369,P<0.01),两组之间的角膜厚度变化无显著性差异(t=1.381,P>0.05);爱丽组共有32眼(84%)角膜厚度增加,而倍然组33眼(87%)角膜厚度增加.结论:对生产工艺要求相对严格的人工泪液能短时间内显著增加近视眼角膜厚度,角膜厚度的变化可作为评估人工泪液等眼药制剂舒适度的客观指标之一.
目的:研究人工淚液愛麗和倍然對成年近視眼角膜厚度的影響.方法:應用Orbscan II角膜地形圖繫統(Orbscan,Inc,Salt Lake City,UT,USA,Version 3.00E)對滴人工淚液愛麗或倍然0.5h後的最薄角膜厚度(THN)變化進行測量,38例(76眼)被隨機分成愛麗組和倍然組,分彆于滴藥前和滴藥後0.5h進行3次THN測量.結果:兩組THN在滴藥前無差異(t=0.264),但滴藥0.5h後兩組THN均顯著增加(愛麗組5.57±7.00μm,t=4.906,P<0.01,倍然組7.89±7.64μm,t=6.369,P<0.01),兩組之間的角膜厚度變化無顯著性差異(t=1.381,P>0.05);愛麗組共有32眼(84%)角膜厚度增加,而倍然組33眼(87%)角膜厚度增加.結論:對生產工藝要求相對嚴格的人工淚液能短時間內顯著增加近視眼角膜厚度,角膜厚度的變化可作為評估人工淚液等眼藥製劑舒適度的客觀指標之一.
목적:연구인공루액애려화배연대성년근시안각막후도적영향.방법:응용Orbscan II각막지형도계통(Orbscan,Inc,Salt Lake City,UT,USA,Version 3.00E)대적인공루액애려혹배연0.5h후적최박각막후도(THN)변화진행측량,38례(76안)피수궤분성애려조화배연조,분별우적약전화적약후0.5h진행3차THN측량.결과:량조THN재적약전무차이(t=0.264),단적약0.5h후량조THN균현저증가(애려조5.57±7.00μm,t=4.906,P<0.01,배연조7.89±7.64μm,t=6.369,P<0.01),량조지간적각막후도변화무현저성차이(t=1.381,P>0.05);애려조공유32안(84%)각막후도증가,이배연조33안(87%)각막후도증가.결론:대생산공예요구상대엄격적인공루액능단시간내현저증가근시안각막후도,각막후도적변화가작위평고인공루액등안약제제서괄도적객관지표지일.
AIM: To study the effects of Sodium Hyaluronate (HA) and Bion Tears on corneal thickness in adult myopic patients.METHODS: A total of 38 cases (76 eyes) were involved in this study. Three consecutive corneal measurements (the thinnest point of the cornea,THN) were evaluated before and half an hour after the instillation of one drop of HA in one eye and Bion Tears in the other at random with the Orbscan Corneal Topography System II (Orbscan,Inc,Salt Lake City,UT,USA,Version 3.00E).RESULTS: There were no significant between-group differences in baseline variable (t=0.264). Thirty minutes after the instillation of HA and Bion tears,THN were significantly increased by 5.57±7.00μm (t=4.906,P<0.01) and 7.89±7.64μm (t=6.369,P<0.01) respectively. However,there were no between-group differences in THN changes(t=1.381,P>0.05).Increase in the corneal thickness were found in 32 eyes (84%) and 33 eyes (87%) for the HA and Bion tears group,respectively.CONCLUSION: Artificial tears including HA and Bion Tears can significantly increase the corneal thickness in a short period of time. Corneal thickness can be used as one of the objective indices for evaluating the quality and therapeutic role of artificial tears.
