CAJ | 학술논문

HIV/AIDS的流行趋势没有减弱的迹象,人们迫切需要新的预防HIV传播的手段.杀微生物剂旨在通过局部用药于阴道或直肠,从而阻止HIV的传播.鉴于目前有大量的杀微生物剂候选物,亟待能够仃效评价其有效性及安全性的动物模型. 通过比较非灵长类小型动物模型与非人灵长类动物模型在评价HIV杀微生物剂的有效性及安全性上的重要作用,该文总结了评价杀微生物剂有效性及安全性的动物模型的优缺点,同时指出了杀微生物剂研究与发展的方向和建议,希望能够对杀微生物剂的研发有所帮助.
HIV/AIDS적류행추세몰유감약적적상,인문박절수요신적예방HIV전파적수단.살미생물제지재통과국부용약우음도혹직장,종이조지HIV적전파.감우목전유대량적살미생물제후선물,극대능구정효평개기유효성급안전성적동물모형. 통과비교비령장류소형동물모형여비인령장류동물모형재평개HIV살미생물제적유효성급안전성상적중요작용,해문총결료평개살미생물제유효성급안전성적동물모형적우결점,동시지출료살미생물제연구여발전적방향화건의,희망능구대살미생물제적연발유소방조.
As the HIV/AIDS pandemic continues unabated, novel prophylactic strategy for the spread of HIV are urgently needed. Topical microbicides are designed to prevent transmission of HIV when applied vaginally or rectally. Although there are many microbicide candidates in the pipeline, animal models for evaluating their safety and efficacy are urgently needed. On the basis of comparing the non-primate small animal models and the non-human primate animal models in evaluating safety and efficacy of HIV microbicides, this review summarizes the major advantages and disadvantages of the relevant animal models. The suggested direction of research that would benefit the development of microbicides is also reviewed.