中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2008年
4期
316-317
,共2页
烟酰胺%肺动脉高压%内皮素1
煙酰胺%肺動脈高壓%內皮素1
연선알%폐동맥고압%내피소1
Nicfinamide%Pulmonary arterial hypertension%Endotheline 1
目的 探讨钾通道开放剂烟酰胺对肺动脉高压患者血浆内皮素的影响.方法 入选66例缺氧性肺动脉高压患者,随机分为烟酰胺治疗组(治疗组)和常规治疗组(对照组),每组33例,测定2组肺动脉高压患者治疗前后血浆内皮素1变化.结果 治疗组治疗后较治疗前血浆内皮素1明显降低(P＜0.01).对照组治疗前后自身比较,血浆内皮素1无明显变化(P＞0.05);治疗组与对照组治疗前后的差值比较有统计学意义(P＜0.01).结论 烟酰胺可保护内皮细胞,减少内皮素1的分泌和释放,对缺氧性肺动脉高压有治疗作用.
目的 探討鉀通道開放劑煙酰胺對肺動脈高壓患者血漿內皮素的影響.方法 入選66例缺氧性肺動脈高壓患者,隨機分為煙酰胺治療組(治療組)和常規治療組(對照組),每組33例,測定2組肺動脈高壓患者治療前後血漿內皮素1變化.結果 治療組治療後較治療前血漿內皮素1明顯降低(P＜0.01).對照組治療前後自身比較,血漿內皮素1無明顯變化(P＞0.05);治療組與對照組治療前後的差值比較有統計學意義(P＜0.01).結論 煙酰胺可保護內皮細胞,減少內皮素1的分泌和釋放,對缺氧性肺動脈高壓有治療作用.
목적 탐토갑통도개방제연선알대폐동맥고압환자혈장내피소적영향.방법 입선66례결양성폐동맥고압환자,수궤분위연선알치료조(치료조)화상규치료조(대조조),매조33례,측정2조폐동맥고압환자치료전후혈장내피소1변화.결과 치료조치료후교치료전혈장내피소1명현강저(P＜0.01).대조조치료전후자신비교,혈장내피소1무명현변화(P＞0.05);치료조여대조조치료전후적차치비교유통계학의의(P＜0.01).결론 연선알가보호내피세포,감소내피소1적분비화석방,대결양성폐동맥고압유치료작용.
Objective To study the influence of Nictinamide on the endotheline(ET-1)in patienta with pulmonary arterial hypertension(PAH).Methods 66 cases of PAH were divided randomly into two groups (n=33for each):the Nictinamide treatment group and the control group.The changes of endotheline were compared before and after treatment.Results After treatment serum endotheline was significantly lower in the treatment group(P＜0.01),but there was no difference in the control group before and aftertreatment(P＞0.05).The significant difference was observed between treatment group and control group(P＜0.01).Conclusion Nictinamide will reduce the level of endothellne and confers some degree therapeutic and preventive value for PAH.
