CAJ | 학술논문

目的分析基于鹿特丹标准诊断的中国人多囊卵巢综合征(PCOS)患者不同月经类型的临床资料及内分泌代谢指标,以指导临床治疗.方法将符合鹿特丹标准的2100例PCOS患者按闭经、月经稀发、月经规律进行分组,分别进行代谢及内分泌等指标的比较.结果 (1)闭经组多毛、多囊卵巢发生率均高于月经稀发组(P＜0.01).(2)闭经组的血清搞睾酮最高,月经稀发组最低(P＜0.01);黄体生成素(LH)在闭经组最高(P＜0.01),在月经稀发组和月经规律组问差异无统计学意义(P＞0.05);黄体生成素/卵泡刺激素(LH/FSH)在月经规律组增高明显(P＜0.01).(3)口服葡萄糖后2 h血糖在闭经组显著增高(P＜0.01).结论符合鹿特丹标准的不同月经类型的PCOS患者具有不同的临床表现及代谢、内分泌特点,对于不同月经类型PCOS患者的治疗也应该个体化.
목적 분석기우록특단표준진단적중국인다낭란소종합정(PCOS)환자불동월경류형적림상자료급내분비대사지표,이지도림상치료.방법 장부합록특단표준적2100례PCOS환자안폐경、월경희발、월경규률진행분조,분별진행대사급내분비등지표적비교.결과 (1)폐경조다모、다낭란소발생솔균고우월경희발조(P＜0.01).(2)폐경조적혈청고고동최고,월경희발조최저(P＜0.01);황체생성소(LH)재폐경조최고(P＜0.01),재월경희발조화월경규률조문차이무통계학의의(P＞0.05);황체생성소/란포자격소(LH/FSH)재월경규률조증고명현(P＜0.01).(3)구복포도당후2 h혈당재폐경조현저증고(P＜0.01).결론 부합록특단표준적불동월경류형적PCOS환자구유불동적림상표현급대사、내분비특점,대우불동월경류형PCOS환자적치료야응해개체화.
Objective To analyze the clinical and metabolic characteristics of Chinese women with different menstrual types.All the women were diagnosed with polycystic ovary syndrome according to the Rotterdam consensus criteria.Methods A total of 2100 patients were divided into three groups:amenorrhea，oligomenorrhea and regular menstruation.The metabolism and endocrine indices were determined and compared among three groups.Results (1)The incidences of hirsutism and PCO were obviously higher in the amenorrhea group than in the oligomenorrhea roup(P＜0.01).(2)The amenorrhea group had the highest level of serum testosterone while the oligomenorrhea group had the lowest.Moreover，the level of luteinizing hormone(LH)was higher in the amenorrhea group than in the other two groups(P＜0.01).However the ratio of LH/FSH increased significantly in the regular menstruation group (P＜0.01).(3)The value of 2 h blood glucose was the highest in the amenorrhea group(P＜0.01).Conclusion PCOS patients with diverse types of menstrual cycle show difierent clinical manifestations and metabolic and endocrine characteristics so that the choice of treatment should be individualized.