北京大学学报（医学版）
北京大學學報（醫學版）
북경대학학보（의학판）
JOURNAL OF BEIJING MEDICAL UNIVERSITY(HEALTH SCIENCES)
2008年
3期
262-269
,共8页
张燕%谢汝萍%沈扬%樊东升
張燕%謝汝萍%瀋颺%樊東升
장연%사여평%침양%번동승
脑血管意外%亚甲基四氢叶酸还原酶%睡眠%多态现象,遗传
腦血管意外%亞甲基四氫葉痠還原酶%睡眠%多態現象,遺傳
뇌혈관의외%아갑기사경협산환원매%수면%다태현상,유전
Cerebrovascular accident%Methylenetetrahydrofolate reductase%Sleep%Polymorphism%genetic
目的:研究中国汉族人群中亚甲基四氢叶酸还原酶基因C677T多态性与睡眠时间之间的相互作用对卒中发病危险的影响.方法:在病例-对照研究和流行病学调查中,分别对245例脑梗死患者,222例脑出血患者及282例无脑血管病对照人群进行了自我报告的睡眠时间分析以及亚甲基四氢叶酸还原酶基因C677T多态性的分析,通过多元logistic同归分析亚甲基四氢叶酸还原酶基因C677T多态性与睡眠时间之间的相互作用对卒中发病危险的影响.结果:经过调整主要混杂因素,多元logistic回归分析显示:(1)睡眠时间延长(每晚睡眠>8h)与脑梗死发病危险显著相关(OR=3.90;95%CI:2.43～6.26);但与脑出血发病危险无显著相关(OR=1.16,95%CI:0.71～1.92);另一方面,失眠(睡眠时间<6 h)与脑梗死及脑出血发病危险均无显著相关.(2)亚甲基四氢叶酸还原酶基因TT基因型显著增加脑梗死发病危险(OR=2.01;95%CI:1.12～3.61);而亚甲基四氢叶酸还原酶基因C677T多态性与脑出血发病危险无显著相关(OR=1.16,95%CI:0.71～1.92).(3)亚甲基四氢叶酸还原酶基因TT基因型与睡眠时间延长之间的相互作用对脑梗死发病危险的影响具有显著的协同作用(OR=6.22;95%CI:2.44～15.83).结论:亚甲基四氢叶酸还原酶基因TT基因型和睡眠时间延长是增加脑梗死发病危险的独立危险因素.中国汉族人群中亚甲基四氢叶酸还原酶基因TT基因型与睡眠时间延长具有对脑梗死发病危险的显著协同作用.
目的:研究中國漢族人群中亞甲基四氫葉痠還原酶基因C677T多態性與睡眠時間之間的相互作用對卒中髮病危險的影響.方法:在病例-對照研究和流行病學調查中,分彆對245例腦梗死患者,222例腦齣血患者及282例無腦血管病對照人群進行瞭自我報告的睡眠時間分析以及亞甲基四氫葉痠還原酶基因C677T多態性的分析,通過多元logistic同歸分析亞甲基四氫葉痠還原酶基因C677T多態性與睡眠時間之間的相互作用對卒中髮病危險的影響.結果:經過調整主要混雜因素,多元logistic迴歸分析顯示:(1)睡眠時間延長(每晚睡眠>8h)與腦梗死髮病危險顯著相關(OR=3.90;95%CI:2.43～6.26);但與腦齣血髮病危險無顯著相關(OR=1.16,95%CI:0.71～1.92);另一方麵,失眠(睡眠時間<6 h)與腦梗死及腦齣血髮病危險均無顯著相關.(2)亞甲基四氫葉痠還原酶基因TT基因型顯著增加腦梗死髮病危險(OR=2.01;95%CI:1.12～3.61);而亞甲基四氫葉痠還原酶基因C677T多態性與腦齣血髮病危險無顯著相關(OR=1.16,95%CI:0.71～1.92).(3)亞甲基四氫葉痠還原酶基因TT基因型與睡眠時間延長之間的相互作用對腦梗死髮病危險的影響具有顯著的協同作用(OR=6.22;95%CI:2.44～15.83).結論:亞甲基四氫葉痠還原酶基因TT基因型和睡眠時間延長是增加腦梗死髮病危險的獨立危險因素.中國漢族人群中亞甲基四氫葉痠還原酶基因TT基因型與睡眠時間延長具有對腦梗死髮病危險的顯著協同作用.
목적:연구중국한족인군중아갑기사경협산환원매기인C677T다태성여수면시간지간적상호작용대졸중발병위험적영향.방법:재병례-대조연구화류행병학조사중,분별대245례뇌경사환자,222례뇌출혈환자급282례무뇌혈관병대조인군진행료자아보고적수면시간분석이급아갑기사경협산환원매기인C677T다태성적분석,통과다원logistic동귀분석아갑기사경협산환원매기인C677T다태성여수면시간지간적상호작용대졸중발병위험적영향.결과:경과조정주요혼잡인소,다원logistic회귀분석현시:(1)수면시간연장(매만수면>8h)여뇌경사발병위험현저상관(OR=3.90;95%CI:2.43～6.26);단여뇌출혈발병위험무현저상관(OR=1.16,95%CI:0.71～1.92);령일방면,실면(수면시간<6 h)여뇌경사급뇌출혈발병위험균무현저상관.(2)아갑기사경협산환원매기인TT기인형현저증가뇌경사발병위험(OR=2.01;95%CI:1.12～3.61);이아갑기사경협산환원매기인C677T다태성여뇌출혈발병위험무현저상관(OR=1.16,95%CI:0.71～1.92).(3)아갑기사경협산환원매기인TT기인형여수면시간연장지간적상호작용대뇌경사발병위험적영향구유현저적협동작용(OR=6.22;95%CI:2.44～15.83).결론:아갑기사경협산환원매기인TT기인형화수면시간연장시증가뇌경사발병위험적독립위험인소.중국한족인군중아갑기사경협산환원매기인TT기인형여수면시간연장구유대뇌경사발병위험적현저협동작용.
Objective: To investigate the interaction between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and sleeping duration on risk of stroke in a Chinese Han ethnic population. Methods: In the case-control study and epidemiological investigation, the self-reported sleep duration and MTHFR C677T polymorphism of 245 patients with cerebral infarction, 222 patients with cerebral hemorrhage and 282 controls were collected. Multiple logistic regression was performed to analyze the interaction between MTHFR C677T polymorphism and sleeping duration on risk of stroke. Results: After adjustment for major confounding variables, multiple logistic regression analysis showed that: (1) There was significant association between long sleep duration (>8 hours of sleep per night) and cerebral infarction (OR=3.90; 95% CI:2.43-6.26), but not for cerebral hemorrhage (OR=1.16, 95% CI: 0.71-1.92). On the other hand, insomnia (sleep duration less than 6 hours) was neither associated with cerebral infarction nor hemorrhage. (2) MTHFR TT genotype increased the risk of cerebral infarction significantly (OR=2.01; 95% CI:1.12-3.61), but not for cerebral hemorrhage (OR=1.16,95% CI:0.71-1.92). (3) There was a significant synergistic effect of interaction between MTHFR TT677 genotype and long sleep duration on risk of cerebral infarction (OR=6.22; 95% CI:2.44-15.83). Conclusion: MTHFR TT677 genotype and long sleep duration increase the risk of cerebral infarction independent of confounding factors, respectively. Furthermore, there is a significant synergistic effect between MTHFR TT677 genotype and long sleep duration on risk of cerebral infarction in the Chinese Han ethnic population.
