CAJ | 학술논문

目的检测PSCA在胰腺癌中的表达情况,探讨PSCA在胰腺癌发病中所起的作用.方法用组织芯片技术构建包含78例导管腺癌,12例慢性胰腺炎患者,10例正常胰腺组织的100点阵的石蜡组织芯片.用免疫组化SP法检测该芯片中PSCA的表达,分析其与胰腺癌I临床病理因素的关系.结果 78例胰腺癌患者中,PSCA阳性表达率为79.5%(62/78),与正常组比较PSCA表达与胰腺癌显著相关(X~2=15.81,P<0.005),与慢性胰腺炎比较PSCA亦与胰腺癌显著相关(X~2=11.33,P<0.005);PSCA表达与年龄、性别、组织分化程度及TNM分期无明显相关性.结论 PSCA阳性表达与胰腺癌相关,可能与胰腺癌的发生发展有着密切关系,但与胰腺癌的临床病理特型无关.
목적 검측PSCA재이선암중적표체정황,탐토PSCA재이선암발병중소기적작용.방법 용조직심편기술구건포함78례도관선암,12례만성이선염환자,10례정상이선조직적100점진적석사조직심편.용면역조화SP법검측해심편중PSCA적표체,분석기여이선암I림상병리인소적관계.결과 78례이선암환자중,PSCA양성표체솔위79.5%(62/78),여정상조비교PSCA표체여이선암현저상관(X~2=15.81,P<0.005),여만성이선염비교PSCA역여이선암현저상관(X~2=11.33,P<0.005);PSCA표체여년령、성별、조직분화정도급TNM분기무명현상관성.결론 PSCA양성표체여이선암상관,가능여이선암적발생발전유착밀절관계,단여이선암적림상병리특형무관.
Objective To investigate the expression of prostate stem cell antigen (PSCA) in human pancreatic carcinoma and explore its role in the oncogenesis of pancreatic cancer. Methods A pancreatic carcinoma tissue microarray was constructed, which contained 10 normal adult pancreas tissues, 12 chronic pancreatitis tissues and 78 pancreatic carcinomas. Immunohistochemistry was employed to detect the expression of PSCA, and the relation between PSCA expression and the clinicopathological factors of pancreatic carcinoma was analyzed. Results The positivity rate of PSCA in pancreatic carcinoma was 79.5 % (62/78), and PSCA staining was more intense in the malignant cells than in the benign cells (x~2=15.81, P<0.005) and chronic pancreatitis tissues (x~2=11.33, P<0.005). No obvious association was found between PSCA expression and the other variables of pancreatic carcinoma (including gender, age at surgery, tumor grade, and TNM stages). Conclusion The expression of PSCA can be related to the development of pancreatic cancer, but not to the clinicopathological factors of the tumor.