中华儿科杂志
中華兒科雜誌
중화인과잡지
Chinese Journal of Pediatrics
2011年
11期
858-861
,共4页
杨子江%李敬风%付利民%雷尚兵%刘俊华%吴勇%胡艳萍
楊子江%李敬風%付利民%雷尚兵%劉俊華%吳勇%鬍豔萍
양자강%리경풍%부이민%뢰상병%류준화%오용%호염평
休克,脓毒性%垂体激素类,后叶%血管升压素类%儿童
休剋,膿毒性%垂體激素類,後葉%血管升壓素類%兒童
휴극,농독성%수체격소류,후협%혈관승압소류%인동
Shock,septic%Pituitary hormones,posterior%Vasopressins%Child
目的 探讨低剂量垂体后叶素对儿童感染性休克的临床疗效.方法 选取2008年1月-2010年12月,我院儿科48例按常规策略治疗满6h休克未纠正的感染性休克患儿并随机(完全随机设计)分成两组(对照组24例、治疗组24例).对照组继续常规策略给予抗感染、容量复苏、纠酸、糖皮质激素及脏器(呼吸、心脏)支持等治疗,并用多巴胺1~15 μg/(kg- min)、去甲肾上腺素0.5 ~2 μg/(kg·min)持续静脉泵入,治疗组6h后加用低剂量垂体后叶素(0.01~0.03 U/min)持续静脉泵入,观察两组纠正休克的疗效.结果 统计资料显示总有效率(显效+有效)治疗组为76.2%,对照组为40.0%;死亡率治疗组为33.3%,对照组为60%,差异有统计学意义(P =0.025).结论 儿童感染性休克按常规策略治疗6h未能纠正时加用低剂量垂体后叶素能显著提高纠正休克的效率,缩短治疗时间,降低死亡率.
目的 探討低劑量垂體後葉素對兒童感染性休剋的臨床療效.方法 選取2008年1月-2010年12月,我院兒科48例按常規策略治療滿6h休剋未糾正的感染性休剋患兒併隨機(完全隨機設計)分成兩組(對照組24例、治療組24例).對照組繼續常規策略給予抗感染、容量複囌、糾痠、糖皮質激素及髒器(呼吸、心髒)支持等治療,併用多巴胺1~15 μg/(kg- min)、去甲腎上腺素0.5 ~2 μg/(kg·min)持續靜脈泵入,治療組6h後加用低劑量垂體後葉素(0.01~0.03 U/min)持續靜脈泵入,觀察兩組糾正休剋的療效.結果 統計資料顯示總有效率(顯效+有效)治療組為76.2%,對照組為40.0%;死亡率治療組為33.3%,對照組為60%,差異有統計學意義(P =0.025).結論 兒童感染性休剋按常規策略治療6h未能糾正時加用低劑量垂體後葉素能顯著提高糾正休剋的效率,縮短治療時間,降低死亡率.
목적 탐토저제량수체후협소대인동감염성휴극적림상료효.방법 선취2008년1월-2010년12월,아원인과48례안상규책략치료만6h휴극미규정적감염성휴극환인병수궤(완전수궤설계)분성량조(대조조24례、치료조24례).대조조계속상규책략급여항감염、용량복소、규산、당피질격소급장기(호흡、심장)지지등치료,병용다파알1~15 μg/(kg- min)、거갑신상선소0.5 ~2 μg/(kg·min)지속정맥빙입,치료조6h후가용저제량수체후협소(0.01~0.03 U/min)지속정맥빙입,관찰량조규정휴극적료효.결과 통계자료현시총유효솔(현효+유효)치료조위76.2%,대조조위40.0%;사망솔치료조위33.3%,대조조위60%,차이유통계학의의(P =0.025).결론 인동감염성휴극안상규책략치료6h미능규정시가용저제량수체후협소능현저제고규정휴극적효솔,축단치료시간,강저사망솔.
Objective To explore the clinical effect of low dose pituitrin in children with septic shock.Methods A total of 48 pediatric cases with septic shock,in whom 6 hours,conventional treatment could not reverse shock from January 2008 to December 2010,were selected for this study.The patients were divided into two groups randomly( completely random design) (control group 24,remedial group 24).The conventional treatment included antibiotics/fluid resuscitation/correcting acid-base imbalance,glucocorticoid,organ(heart/lung) support,dopamine 1-15 μg/( kg · min) and norepinephrine 0.5-2 μg/( kg · min) pumped in continuously in the control group.In initial 6 hours the same treatment was given to the remedial group,while low dose pituitrin (0.01-0.03 U/min) was pumped additionally during the rest of time.The therapeutic effect on correcting shock was evaluated in both groups.Results The total effective rate was 76.2% in the remedial group and 40.0% in the control group; the mortality was 33.3% and 60%respectively.The difference between both groups was significant (P =0.025 ).Conclusion Low dose pituitrin could improve the clinical effect significantly in children with septic shock in whom 6 hours conventional treatment failed to correct shock,shorten the total periods of treatment,and decrease mortality.