CAJ | 학술논문

为了深入了解氯喹药代动力学有关情况，用高效液相色谱检测4名志愿者口服氯喹总量分别为600mg、600mg、900mg和1 200mg后，血药浓度168h后尚有141μg/L、134μg/L、208μg/L和298μg/L，均明显高于有效杀灭疟原虫20μg／L浓度。用单剂600mg和首日600mg，次日300mg氯喹治疗间日疟现症病人各1例，追踪观察28h均无症状复发和原虫再现，获得痊愈。结果表明口服氯喹在人体内清除非常缓慢，维持有效杀灭疟原虫时间长，是治疗间日疟、三日疟和卵型疟的首选药。
위료심입료해록규약대동역학유관정황，용고효액상색보검측4명지원자구복록규총량분별위600mg、600mg、900mg화1 200mg후，혈약농도168h후상유141μg/L、134μg/L、208μg/L화298μg/L，균명현고우유효살멸학원충20μg／L농도。용단제600mg화수일600mg，차일300mg록규치료간일학현증병인각1례，추종관찰28h균무증상복발화원충재현，획득전유。결과표명구복록규재인체내청제비상완만，유지유효살멸학원충시간장，시치료간일학、삼일학화란형학적수선약。
The contents of chloroquine in blood were determined by HPLC in 4 volunteers taking orally 600mg, 600mg, 900mg, and 1200mg of chloroquine respectively. 168 hours after administration, the concentration were 141μg/L, 134μg/L, 208μg/L, and 298 μg/L, which were obviously higher than the effective level (20μg/L) of chloroquine a gainst Plasmodium. Two acute cases with vivax malaria were experimentally treated with a single dose of 600mg, or 300mg, 600mg in 2 days of chloroquine. No relapse of symptoms or parasite presented during 28 days' follow-up study. The results showed that the chloroquine could maintain effective concentration in blood for relatively a long time and which would provide scientific basis for re-assessment of malaria treatment program.