CAJ | 학술논문

目的　为探讨绝经后女性2型糠尿病患者性激素水平变化及与胰岛素抵抗的关系。方法　对32例绝经1年以上女性2型糖尿病患者(Ⅰ组，平均年龄57.8±3.7岁)、25例绝经1年以上无糖尿病健康妇女(Ⅱ组，平均年龄58.3±3.2岁)及22例无糖尿病的健康育龄行经妇女(Ⅲ组，平均年龄40.9±2.6岁)的血清雌二醇(E2)、促卵泡剌激素(FSH)、促黄体生成素(LH)、睾酮(T)、血浆葡萄糖(G)、血浆胰岛素(INS)及胰岛素敏感指数(ISI)进行检测。结果　Ⅰ组E2水平较Ⅱ、Ⅲ组明显降低，FSH、LH、T水平显著增高。线性相关分析发现，E2与FSH、LH、T、INS呈显著负相关，而E2与ISI呈显著正相关，总体相关系数分别为-0.51、-0.49、-0.58、-0.38、0.45(P值均＜0.01)。结论　绝经后女性2型糖尿病患者存在严重的性激素失调，且与胰岛素抵抗并存，可能参与绝经后女性2型糖尿病的发生和发展。
목적　위탐토절경후녀성2형강뇨병환자성격소수평변화급여이도소저항적관계。방법　대32례절경1년이상녀성2형당뇨병환자(Ⅰ조，평균년령57.8±3.7세)、25례절경1년이상무당뇨병건강부녀(Ⅱ조，평균년령58.3±3.2세)급22례무당뇨병적건강육령행경부녀(Ⅲ조，평균년령40.9±2.6세)적혈청자이순(E2)、촉란포랄격소(FSH)、촉황체생성소(LH)、고동(T)、혈장포도당(G)、혈장이도소(INS)급이도소민감지수(ISI)진행검측。결과　Ⅰ조E2수평교Ⅱ、Ⅲ조명현강저，FSH、LH、T수평현저증고。선성상관분석발현，E2여FSH、LH、T、INS정현저부상관，이E2여ISI정현저정상관，총체상관계수분별위-0.51、-0.49、-0.58、-0.38、0.45(P치균＜0.01)。결론　절경후녀성2형당뇨병환자존재엄중적성격소실조，차여이도소저항병존，가능삼여절경후녀성2형당뇨병적발생화발전。
Objective to study the changes of sex hormone in postmenopausal women with type-2 diabetes mellitus and the relationship between sex hormones and insulin resistance.Methods 32 postmenopausal women with type-2 diabetes mellitus(group Ⅰ,57.8±3.7 years);25 postmenopausal women without diabetes mellitus(groupⅡ,58.3±3.2years) and 22 premenopausal women without diabetes mellitus as control(groupⅢ,40.9±2.6years) were selected to compare the serum Levels of estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH),testosterone(T).plasma glucose(G),insulin (INS) and insulin sensistivity index (ISI).Results Analysis of variance demonstrated that menopause was associated with significantly higher serum levels of FSH,LH,T and lower serum levels of E2.Correelation analysis showed that serum E2 level was negatively correlated to serum of FSH,LH,T,INS(-0.51、-0.49、-0.58、-0.38.p＜0.01)，but positively associated with ISI(0.45,P＜0.01)。Conclusion The study indicates that significantly lower level of estradiol,high level of testosterone and imbalance sex hormones and insulin resistance play an important role in the development of type-2 diabetes mellitus.